Known targets — ChEMBL curated mechanism
CACNA1CCACNA1DCACNA1FCACNA1SCSF1RDRD2FLT1FLT3FLT4HTR1BHTR1DHTR1FKDRKITMETOPRD1OPRK1OPRM1PDGFRAPDGFRBRET
The experimentally established mechanism targets of Malic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA4 | P22748 | 4/20 | 0.94 |
| ▸ | CTSL | P07711 | 1/20 | 0.46 |
| ▸ | CA2 | P00918 | 1/20 | 0.43 |
| ▸ | SLC22A16 | Q86VW1 | 1/20 | 0.42 |
| ▸ | CPT2 | P23786 | 1/20 | 0.34 |
| ▸ | CPT1A | P50416 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | CASP1 | P29466 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.31 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.31 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Malic Acid SCHEMBL29373911 | 0.97 | CA4 (0.89) | CA4CTSLCA2SLC22A16CPT2 | |
| Malic Acid SCHEMBL5676981 | 0.97 | CA4 (0.89) | CA4CTSLCA2SLC22A16CPT2 | |
| Malic Acid SCHEMBL6680483 | 0.95 | CA4 (0.84) | CA4CTSLCA2SLC22A16CPT2 | |
| Malic Acid SCHEMBL18393648 | 0.94 | CA4 (0.94) | CA4CTSLCA2SLC22A16CPT2 | |
| Malic Acid SCHEMBL21815132 | 0.94 | CA4 (1.00) | CA4CTSLCA2SLC22A16CPT2 | |
| Malic Acid SCHEMBL162118 | 0.94 | CA4 (0.94) | CA4CTSLCA2SLC22A16CPT2 | |
| Malic Acid SCHEMBL20994738 | 0.94 | — | — | |
| Malic Acid SCHEMBL21815634 | 0.94 | CA4 (0.94) | CA4CTSLCA2SLC22A16CPT2 | |
| Malic Acid SCHEMBL3593172 | 0.94 | CA4 (0.94) | CA4CTSLCA2SLC22A16CPT2 | |
| Malic Acid SCHEMBL118155 | 0.94 | CA4 (0.94) | CA4CTSLCA2SLC22A16CPT2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1492 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3570977-B1 | A PROCESS FOR PREPARING A MOLDING COMPRISING ZINC AND A TITANIUM-CONTAINING ZEOLITE | BASF SE (DE) | 2026-04-08 | — | — | EP | claimed |
| EP-4017462-B1 | ORAL CARE COMPOSITIONS CONTAINING INULIN | COLGATE PALMOLIVE CO (US) | 2026-04-01 | — | — | EP | claimed |
| EP-3773453-B1 | ORAL CARE COMPOSITIONS FOR PROMOTING GUM HEALTH | PROCTER & GAMBLE (US) | 2026-04-01 | — | — | EP | claimed |
| EP-4037638-B1 | ORAL CARE COMPOSITIONS COMPRISING STANNOUS ION SOURCE, NEUTRAL AMINO ACID, AND POLYPHOSPHATE | PROCTER & GAMBLE (US) | 2026-04-01 | — | — | EP | claimed |
| US-20250281374-A1 | Dentifrice Compositions Comprising Tin Ions | PROCTER & GAMBLE (US) | 2025-09-11 | — | — | US | claimed |
| US-12350353-B2 | Synthetic enamel and uses thereof | TRUSTEES OF BOSTON UNIVERSITY (US) | 2025-07-08 | — | — | US | claimed |
| US-12337046-B2 | Oral care compositions comprising tin ions | PROCTER & GAMBLE (US) | 2025-06-24 | — | — | US | claimed |
| US-12337047-B2 | Dentifrice compositions comprising tin ions | THE PROCTER & GAMBLE COMPANY (US) | 2025-06-24 | — | — | US | claimed |
| CN-119873821-A | Rice hull sodium ion battery carbon negative electrode material and preparation method thereof | 福建世记华钠新能源科技集团有限公司 | 2025-04-25 | — | — | CN | claimed |
| CN-119776007-A | Cu-MTD etching solution composition for protecting oxide semiconductor | 四川和晟达电子科技有限公司 | 2025-04-08 | — | — | CN | claimed |
| US-20040042978-A1 | Method and composition for the treatment of epidermal irritations and infections | MEININGER, LEIGH R., TRUSTEE IN BANKRUPTCY | 2004-03-04 | — | — | US | claimed |
| US-20040033260-A1 | Compositions for prevention and treatment of cold and influenza-like symptoms comprising chelated zinc | THE PROCTER & GAMBLE COMPANY (US) | 2004-02-19 | — | — | US | claimed |
| CN-1311628-A | Methods and compositions for treating skin allergies and infections | WILLIAM J EMBRO (US) | 2001-09-05 | — | — | CN | claimed |
| EP-1085804-A1 | METHOD AND COMPOSITION FOR THE TREATMENT OF EPIDERMAL IRRITATIONS AND INFECTIONS | Embro, William J. (US) | 2001-03-28 | — | — | EP | claimed |
| WO-1999063816-A1 | METHOD AND COMPOSITION FOR THE TREATMENT OF EPIDERMAL IRRITATIONS AND INFECTIONS | EMBRO WILLIAM J (US) | 1999-12-16 | — | — | WO | claimed |
| CN-1161776-A | Green-plant treatment method capable of greatly prolonging period of inserting in bottle and storage period, and treatment liquid thereof | ZHANG CHENGZHI (CN) | 1997-10-15 | — | — | CN | claimed |
| CN-1144599-A | Treatment method and liquid for withered green plant recovering its active state | ZHANG CHENGZHI (CN) | 1997-03-12 | — | — | CN | claimed |
| CN-1012682-B | POLYVINYL CHLORIDE RESIN COMPOSITION FOR POWDER MOLDING | SUMITOMO CHEMICAL CO (JP) | 1991-05-29 | — | — | CN | claimed |
| US-4861816-A | Polyvinyl chloride resin composition for powder molding | SUMITOMO CHEMICAL COMPANY (JP) | 1989-08-29 | — | — | US | claimed |
| CN-87105970-A | The poly (vinyl chloride) resin composition that is used for powder molding | — | 1988-08-10 | — | — | CN | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040033260-A1 | Compositions for prevention and treatment of cold and influenza-like symptoms comprising chelated zinc | ZC3HAV1, ZC3HAV1L, SLC39A3 | CA4 116/4885CTSL 1082/4885CA2 159/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.