Known targets — ChEMBL curated mechanism
CACNA1CCACNA1DCACNA1FCACNA1SCSF1RDRD2FLT1FLT3FLT4HTR1BHTR1DHTR1FKDRKITMETOPRD1OPRK1OPRM1PDGFRAPDGFRBRET
The experimentally established mechanism targets of Malic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA4 | P22748 | 4/20 | 0.94 |
| ▸ | CTSL | P07711 | 1/20 | 0.46 |
| ▸ | CA2 | P00918 | 1/20 | 0.43 |
| ▸ | SLC22A16 | Q86VW1 | 1/20 | 0.42 |
| ▸ | CPT2 | P23786 | 1/20 | 0.34 |
| ▸ | CPT1A | P50416 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | CASP1 | P29466 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.31 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.31 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Malic Acid SCHEMBL1093517 | 0.94 | CA4 (0.94) | CA4CTSLCA2SLC22A16CPT2 | |
| Malic Acid SCHEMBL674137 | 0.94 | CA4 (0.94) | CA4CTSLCA2SLC22A16CPT2 | |
| Malic Acid SCHEMBL20994738 | 0.94 | — | — | |
| Malic Acid SCHEMBL121544 | 0.94 | CA4 (0.94) | CA4CTSLCA2SLC22A16CPT2 | |
| Malic Acid SCHEMBL162118 | 0.94 | CA4 (0.94) | CA4CTSLCA2SLC22A16CPT2 | |
| Malic Acid SCHEMBL3596014 | 0.94 | CA4 (0.94) | CA4CTSLCA2SLC22A16CPT2 | |
| Malic Acid SCHEMBL21815132 | 0.94 | CA4 (1.00) | CA4CTSLCA2SLC22A16CPT2 | |
| Malic Acid SCHEMBL21815634 | 0.94 | CA4 (0.94) | CA4CTSLCA2SLC22A16CPT2 | |
| Malic Acid SCHEMBL3593172 | 0.94 | CA4 (0.94) | CA4CTSLCA2SLC22A16CPT2 | |
| Malic Acid SCHEMBL5013575 | 0.94 | CA4 (0.94) | CA4CTSLCA2SLC22A16CPT2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 284 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3773453-B1 | ORAL CARE COMPOSITIONS FOR PROMOTING GUM HEALTH | PROCTER & GAMBLE (US) | 2026-04-01 | — | — | EP | claimed |
| EP-4037638-B1 | ORAL CARE COMPOSITIONS COMPRISING STANNOUS ION SOURCE, NEUTRAL AMINO ACID, AND POLYPHOSPHATE | PROCTER & GAMBLE (US) | 2026-04-01 | — | — | EP | claimed |
| EP-4687815-A1 | ORAL CARE COMPOSITIONS FOR PROMOTING GUM HEALTH | The Procter & Gamble Company (US) | 2026-02-11 | — | — | EP | claimed |
| EP-4687816-A1 | ORAL CARE COMPOSITIONS FOR PROMOTING GUM HEALTH | The Procter & Gamble Company (US) | 2026-02-11 | — | — | EP | claimed |
| EP-4687817-A1 | ORAL CARE COMPOSITIONS FOR PROMOTING GUM HEALTH | The Procter & Gamble Company (US) | 2026-02-11 | — | — | EP | claimed |
| US-20260034041-A1 | ORAL CARE COMPOSITIONS FOR PROMOTING GUM HEALTH | PROCTER & GAMBLE (US) | 2026-02-05 | — | — | US | claimed |
| US-20260027028-A1 | ORAL CARE COMPOSITIONS FOR PROMOTING GUM HEALTH | PROCTER & GAMBLE (US) | 2026-01-29 | — | — | US | claimed |
| US-20260027029-A1 | ORAL CARE COMPOSITIONS FOR PROMOTING GUM HEALTH | PROCTER & GAMBLE (US) | 2026-01-29 | — | — | US | claimed |
| WO-2024207174-A1 | ORAL CARE COMPOSITIONS FOR PROMOTING GUM HEALTH | THE PROCTER & GAMBLE COMPANY (US) | 2024-10-10 | — | — | WO | claimed |
| WO-2024207170-A1 | ORAL CARE COMPOSITIONS FOR PROMOTING GUM HEALTH | THE PROCTER & GAMBLE COMPANY (US) | 2024-10-10 | — | — | WO | claimed |
| CN-106074192-A | Oxidation resistant oral care composition | 好来化工(中山)有限公司 | 2016-11-09 | — | — | CN | claimed |
| US-8962057-B2 | Methods for improving taste and oral care compositions with improved taste | THE PROCTER & GAMBLE COMPANY (US) | 2015-02-24 | — | — | US | claimed |
| EP-2621462-A1 | ORAL CARE COMPOSITIONS WITH IMPROVED FLAVOR | The Procter and Gamble Company (US) | 2013-08-07 | — | — | EP | claimed |
| CN-103140209-A | Oral care compositions with improved flavor | PROCTER & GAMBLE | 2013-06-05 | — | — | CN | claimed |
| CN-102612385-A | Method for improving taste and oral care composition with improved taste | PROCTER & GAMBLE | 2012-07-25 | — | — | CN | claimed |
| US-20120082628-A1 | Oral Care Compositions With Improved Flavor | THE PROCTER & GAMBLE COMPANY | 2012-04-05 | — | — | US | claimed |
| WO-2012044728-A1 | ORAL CARE COMPOSITIONS WITH IMPROVED FLAVOR | THE PROCTER & GAMBLE COMPANY (US) | 2012-04-05 | — | — | WO | claimed |
| EP-2424621-A2 | METHODS FOR IMPROVING TASTE AND ORAL CARE COMPOSITIONS WITH IMPROVED TASTE | The Procter & Gamble Company (US) | 2012-03-07 | — | — | EP | claimed |
| US-20100278991-A1 | Methods for Improving Taste and Oral Care Compositions With Improved Taste | THE PROCTER & GAMBLE COMPANY | 2010-11-04 | — | — | US | claimed |
| WO-2010126753-A2 | METHODS FOR IMPROVING TASTE AND ORAL CARE COMPOSITIONS WITH IMPROVED TASTE | THE PROCTER & GAMBLE COMPANY (US) | 2010-11-04 | — | — | WO | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20260027028-A1 | ORAL CARE COMPOSITIONS FOR PROMOTING GUM HEALTH | TAS2R40, MUC1, TAS1R1 | CA4 489/4885CTSL 3899/4885CA2 93/4885 |
| US-20260034041-A1 | ORAL CARE COMPOSITIONS FOR PROMOTING GUM HEALTH | KCNN1, TAS1R1, MUC1 | CA4 994/4885CTSL 1885/4885CA2 181/4885 |
| US-20260027029-A1 | ORAL CARE COMPOSITIONS FOR PROMOTING GUM HEALTH | CACNA1H, KCNN1, TAS2R40 | CA4 977/4885CTSL 1473/4885CA2 489/4885 |
| US-20120082628-A1 | Oral Care Compositions With Improved Flavor | TRPA1, TAS2R40, TAS2R30 | CA4 1013/4885CTSL 4683/4885CA2 289/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.