SCHEMBL12154696

SCHEMBL12154696

Cc1ccc(C2(c3ccc(N4C(=O)C5C6C(=O)N(C)C(=O)C6C5C4=O)cc3)c3ccccc3-c3ccccc32)cc1

nearest known ligand 0.45

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
PGR P06401 1/20 0.45
TP53 P04637 1/20 0.44
ACHE P22303 1/20 0.44
SMN1; SMN2 Q16637 3/20 0.42
MAPT P10636 2/20 0.42
KDM4E B2RXH2 1/20 0.42
MEN1 O00255 1/20 0.42
LMNA P02545 1/20 0.42
OPRK1 P41145 1/20 0.42
KMT2A Q03164 1/20 0.42
ADCY2 Q08462 5/20 0.42
ALDH1A1 P00352 3/20 0.40
GAA P10253 1/20 0.40
CACNA1B Q00975 1/20 0.40
APBA1 Q02410 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL13400456 0.93 TP53 (0.43) PGRTP53ACHESMN1; SMN2MAPT
SCHEMBL13400441 0.92 ACHE (0.42) PGRTP53ACHESMN1; SMN2MAPT
SCHEMBL16201614 0.86 ACHE (0.49) PGRTP53ACHESMN1; SMN2MEN1
SCHEMBL10299746 0.82 PGR (0.60) PGRSMN1; SMN2MAPTKDM4EMEN1
SCHEMBL19412441 0.81 ACHE (0.44) PGRTP53ACHESMN1; SMN2MAPT
SCHEMBL17570488 0.80 TP53 (0.57) TP53SMN1; SMN2MAPTLMNAALDH1A1
SCHEMBL760025 0.79 ALDH1A1 (0.51) PGRKDM4EMEN1KMT2AALDH1A1
SCHEMBL16521680 0.76 CA9 (0.53) PGRKDM4EMEN1KMT2AALDH1A1
SCHEMBL16521689 0.76 CA9 (0.53) PGRKDM4EMEN1KMT2AALDH1A1
SCHEMBL25751092 0.76 PGR (0.47) PGRKDM4EMEN1KMT2AALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8049850-B2 Liquid crystal display device, optical compensatory sheet, and polarizer and liquid crystal display device employing the same FUJIFILM CORPORATION (JP) 2011-11-01 US disclosed
US-8049850-B2 Liquid crystal display device, optical compensatory sheet, and polarizer and liquid crystal display device employing the same FUJIFILM CORPORATION (JP) 2011-11-01 US disclosed
US-20090122243-A1 Liquid Crystal Display Device, Optical Compensatory Sheet, and Polarizer and Liquid Crystal Display Device Employing the Same FUJIFILM CORPORATION (JP) 2009-05-14 US disclosed
US-20090122243-A1 Liquid Crystal Display Device, Optical Compensatory Sheet, and Polarizer and Liquid Crystal Display Device Employing the Same FUJIFILM CORPORATION (JP) 2009-05-14 US disclosed