Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.46 |
| ▸ | NPC1 | O15118 | 3/20 | 0.46 |
| ▸ | PKM | P14618 | 2/20 | 0.46 |
| ▸ | RAB9A | P51151 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | TP53 | P04637 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.46 |
| ▸ | CCR1 | P32246 | 2/20 | 0.46 |
| ▸ | CCR5 | P51681 | 2/20 | 0.46 |
| ▸ | CCR8 | P51685 | 2/20 | 0.46 |
| ▸ | METAP1 | P53582 | 2/20 | 0.45 |
| ▸ | METAP2 | P50579 | 1/20 | 0.45 |
| ▸ | CBFB | Q13951 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | BLM | P54132 | 1/20 | 0.45 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28001914 | 0.86 | NPC1 (0.50) | KDM4ENPC1PKMRAB9AALDH1A1 | |
| SCHEMBL3423163 | 0.83 | KDM4E (0.50) | KDM4ENPC1PKMRAB9AALDH1A1 | |
| SCHEMBL7576751 | 0.81 | CCR1 (0.53) | KDM4ENPC1PKMRAB9AALDH1A1 | |
| SCHEMBL16806017 | 0.81 | KDM4E (0.50) | KDM4ENPC1PKMRAB9AALDH1A1 | |
| SCHEMBL31558882 | 0.81 | KDM4E (0.56) | KDM4ENPC1PKMRAB9AALDH1A1 | |
| SCHEMBL16787395 | 0.79 | CYP19A1 (0.42) | NPC1RAB9AALDH1A1TP53HPGD | |
| SCHEMBL30090533 | 0.79 | L3MBTL1 (0.44) | KDM4ENPC1PKMRAB9AALDH1A1 | |
| SCHEMBL31039969 | 0.79 | L3MBTL1 (0.44) | KDM4ENPC1PKMRAB9AALDH1A1 | |
| SCHEMBL1016812 | 0.79 | SMN1; SMN2 (0.49) | KDM4ENPC1PKMRAB9AALDH1A1 | |
| SCHEMBL18296273 | 0.79 | KDM1A (0.48) | KDM4ENPC1RAB9ACCR1CCR5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1789390-B1 | PYRIDYL INHIBITORS OF HEDGEHOG SIGNALLING | GENENTECH INC (US) | 2011-11-09 | — | — | EP | disclosed |