Predicted protein targets (top 1)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12787399 | 0.54 | MTOR (0.38) | ALDH1A1 | |
| SCHEMBL19657080 | 0.50 | ALDH1A1 (0.56) | ALDH1A1 | |
| SCHEMBL18407474 | 0.48 | ALDH1A1 (0.32) | ALDH1A1 | |
| SCHEMBL21093207 | 0.48 | SMN1; SMN2 (0.38) | ALDH1A1 | |
| SCHEMBL23547316 | 0.47 | DAPK1 (0.38) | — | |
| SCHEMBL19366633 | 0.47 | ALDH1A1 (0.41) | ALDH1A1 | |
| SCHEMBL27405153 | 0.47 | ADORA1 (0.41) | — | |
| SCHEMBL1520741 | 0.47 | ALDH1A1 (0.60) | ALDH1A1 | |
| SCHEMBL12580853 | 0.47 | PIK3CA (0.35) | — | |
| SCHEMBL13180796 | 0.47 | ALDH1A1 (0.33) | ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9676808-B2 | 2′,4′-substituted nucleosides as antiviral agents | GILEAD PHARMASSET LLC (US) | 2017-06-13 | — | — | US | disclosed |
| US-20160280735-A1 | 2',4'-SUBSTITUTED NUCLEOSIDES AS ANTIVIRAL AGENTS | GILEAD SCIENCES, INC. | 2016-09-29 | — | — | US | disclosed |
| US-9296777-B2 | 2′,4′-substituted nucleosides as antiviral agents | GILEAD PHARMASSET LLC (US) | 2016-03-29 | — | — | US | disclosed |
| US-20140235563-A1 | 2',4'-SUBSTITUTED NUCLEOSIDES AS ANTIVIRAL AGENTS | GILEAD SCIENCES, INC. (US) | 2014-08-21 | — | — | US | disclosed |
| US-8765710-B2 | 2′,4′-substituted nucleosides as antiviral agents | GILEAD PHARMASSET LLC (US) | 2014-07-01 | — | — | US | disclosed |
| US-20120232029-A1 | 2',4'-SUBSTITUTED NUCLEOSIDES AS ANTIVIRAL AGENTS | PHARMASSET, INC. (US) | 2012-09-13 | — | — | US | disclosed |
| US-20090318380-A1 | 2',4'-SUBSTITUTED NUCLEOSIDES AS ANTIVIRAL AGENTS | PHARMASSET, INC. (US) | 2009-12-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090318380-A1 | 2',4'-SUBSTITUTED NUCLEOSIDES AS ANTIVIRAL AGENTS | HAVCR2, NUDT1, NT5C3B | ALDH1A1 961/4885 |
| US-20120232029-A1 | 2',4'-SUBSTITUTED NUCLEOSIDES AS ANTIVIRAL AGENTS | HAVCR2, NUDT1, NT5C3B | ALDH1A1 961/4885 |
| US-20140235563-A1 | 2',4'-SUBSTITUTED NUCLEOSIDES AS ANTIVIRAL AGENTS | HAVCR2, NUDT1, NT5C3B | ALDH1A1 961/4885 |
| US-20160280735-A1 | 2',4'-SUBSTITUTED NUCLEOSIDES AS ANTIVIRAL AGENTS | HAVCR2, NUDT1, NT5C3B | ALDH1A1 961/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.