SCHEMBL12172946

SCHEMBL12172946

Nc1c(/N=N/c2ccccc2)ccc2cc(S(=O)(=O)O)c(/N=N/c3cccc(Nc4nc(F)nc(Nc5cccc(Cl)c5)n4)c3)c(O)c12

nearest known ligand 0.51

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
▸ ENPP2 Q13822 8/20 0.51
▸ FUT8 Q9BYC5 1/20 0.45
▸ CYP1A2 P05177 3/20 0.40
▸ PHLPP2 Q6ZVD8 2/20 0.37
▸ PRMT3 O60678 1/20 0.37
▸ EP300 Q09472 1/20 0.37
▸ PRMT6 Q96LA8 1/20 0.37
▸ PRMT1 Q99873 1/20 0.37
▸ CD40 P25942 1/20 0.36
▸ CD40LG P29965 1/20 0.36
▸ CYP2C9 P11712 1/20 0.36
▸ MAPK1 P28482 1/20 0.36
▸ DNASE1L3 Q13609 1/20 0.36
▸ SUMO2 P61956 1/20 0.36
▸ SUMO1 P63165 1/20 0.36
▸ SENP7 Q9BQF6 1/20 0.36
▸ SENP2 Q9HC62 1/20 0.36
▸ SENP1 Q9P0U3 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL14981561 0.86 ENPP2 (0.54) ENPP2FUT8CYP1A2PHLPP2PRMT3
SCHEMBL18218144 0.83 FUT8 (0.56) ENPP2FUT8CYP1A2PHLPP2PRMT1
SCHEMBL12172927 0.83 FUT8 (0.56) ENPP2FUT8CYP1A2PHLPP2PRMT1
SCHEMBL13481857 0.83 ENPP2 (0.48) ENPP2FUT8CYP1A2PHLPP2PRMT3
SCHEMBL16387115 0.82 ENPP2 (0.51) ENPP2FUT8CYP1A2PHLPP2PRMT3
SCHEMBL12943143 0.80 ENPP2 (0.68) ENPP2CYP1A2PHLPP2PRMT3EP300
SCHEMBL18218142 0.79 FUT8 (0.62) ENPP2FUT8CYP1A2PHLPP2CD40
SCHEMBL14134065 0.78 ENPP2 (0.46) ENPP2FUT8CYP1A2PHLPP2PRMT3
SCHEMBL13481841 0.78 ENPP2 (0.44) ENPP2FUT8CYP1A2PHLPP2PRMT3
SCHEMBL16557867 0.78 ENPP2 (0.45) ENPP2FUT8CYP1A2PHLPP2PRMT3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-9403987-B2 Charged particles BASF SE (DE) 2016-08-02 — — US disclosed
US-20120229884-A1 CHARGED PARTICLES BASF SE (DE) 2012-09-13 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20120229884-A1 CHARGED PARTICLES POLE3, POLD3, IPO4 ENPP2 1649/4885FUT8 769/4885CYP1A2 4304/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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