Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KIF11 | P52732 | 2/20 | 0.53 |
| ▸ | XDH | P47989 | 1/20 | 0.40 |
| ▸ | PTPN5 | P54829 | 1/20 | 0.40 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.39 |
| ▸ | FEN1 | P39748 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 2/20 | 0.38 |
| ▸ | RAB9A | P51151 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.38 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.38 |
| ▸ | CASP3 | P42574 | 1/20 | 0.38 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.38 |
| ▸ | RELA | Q04206 | 1/20 | 0.38 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.38 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.38 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | ATG4B | Q9Y4P1 | 1/20 | 0.38 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.38 |
| ▸ | STS | P08842 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26179240 | 0.96 | KIF11 (0.50) | KIF11XDHPTPN5ALOX5APFEN1 | |
| SCHEMBL15853159 | 0.89 | ALDH1A1 (0.43) | KIF11XDHPTPN5NPC1RAB9A | |
| SCHEMBL30395197 | 0.85 | KIF11 (0.57) | KIF11XDHPTPN5NPC1RAB9A | |
| SCHEMBL19797926 | 0.81 | ESR2 (0.59) | KIF11PTPN5ALDH1A1ESR2TRPV1 | |
| SCHEMBL25708832 | 0.79 | MGAT2 (0.38) | KIF11XDHNPC1ALDH1A1LMNA | |
| SCHEMBL497451 | 0.78 | KIF11 (0.47) | KIF11XDHALDH1A1 | |
| SCHEMBL30566936 | 0.78 | KIF11 (0.47) | KIF11XDHALDH1A1 | |
| SCHEMBL15832009 | 0.77 | KIF11 (0.49) | KIF11XDHPTPN5ALDH1A1 | |
| SCHEMBL24617123 | 0.77 | KIF11 (0.49) | KIF11PTPN5ESR2TRPV1 | |
| SCHEMBL17708066 | 0.77 | KIF11 (0.42) | KIF11NPC1RAB9AALDH1A1PLA2G1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9133170-B2 | Inhibitors of HCV NS5A | HOFFMANN-LA ROCHE INC. (US) | 2015-09-15 | — | — | US | disclosed |
| US-20150166514-A1 | INHIBITORS OF HCV NS5A | HOFFMANN-LA ROCHE INC. (US) | 2015-06-18 | — | — | US | disclosed |
| US-20120328565-A1 | ANTIVIRAL COMPOUNDS | BRINKMAN JOHN A (US) | 2012-12-27 | — | — | US | disclosed |
| US-20120230951-A1 | ANTIVIRAL COMPOUNDS | ALAM MUZAFFAR (US) | 2012-09-13 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120328565-A1 | ANTIVIRAL COMPOUNDS | EIF2AK2, HAVCR2, MAVS | KIF11 2785/4885XDH 202/4885PTPN5 2112/4885 |
| US-20120230951-A1 | ANTIVIRAL COMPOUNDS | HAVCR2, EIF2AK2, MAVS | KIF11 3013/4885XDH 536/4885PTPN5 2936/4885 |
| US-20150166514-A1 | INHIBITORS OF HCV NS5A | HAVCR2, EIF2AK2, MAVS | KIF11 3031/4885XDH 3273/4885PTPN5 246/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.