Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.58 |
| ▸ | AURKA | O14965 | 2/20 | 0.58 |
| ▸ | LMNA | P02545 | 1/20 | 0.58 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.57 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.57 |
| ▸ | PIM1 | P11309 | 1/20 | 0.57 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.57 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.57 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.57 |
| ▸ | HIPK2 | Q9H2X6 | 1/20 | 0.57 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.57 |
| ▸ | CSNK1G1 | Q9HCP0 | 1/20 | 0.57 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.57 |
| ▸ | MGAM | O43451 | 2/20 | 0.54 |
| ▸ | CA12 | O43570 | 2/20 | 0.54 |
| ▸ | CA1 | P00915 | 2/20 | 0.54 |
| ▸ | CA2 | P00918 | 2/20 | 0.54 |
| ▸ | CA9 | Q16790 | 2/20 | 0.54 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.53 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12177373 | 0.94 | MGAM (0.61) | TDP1AURKALMNADAPK3DYRK3 | |
| SCHEMBL12177688 | 0.93 | CA9 (0.57) | TDP1AURKALMNADAPK3DYRK3 | |
| SCHEMBL12177573 | 0.93 | AURKA (0.60) | TDP1AURKALMNADAPK3DYRK3 | |
| SCHEMBL12177288 | 0.92 | TDP1 (0.55) | TDP1AURKALMNADAPK3DYRK3 | |
| SCHEMBL12177483 | 0.88 | TDP1 (0.51) | TDP1AURKALMNADAPK3DYRK3 | |
| SCHEMBL12177755 | 0.85 | AURKA (0.60) | TDP1AURKALMNAMGAMCA12 | |
| SCHEMBL12177727 | 0.85 | ALDH1A1 (0.59) | TDP1AURKALMNAMGAMCA12 | |
| SCHEMBL12177693 | 0.85 | TDP1 (0.50) | TDP1AURKALMNAMGAMCA12 | |
| SCHEMBL12177724 | 0.85 | ALDH1A1 (0.59) | TDP1AURKALMNAMGAMCA12 | |
| SCHEMBL12177391 | 0.84 | PTPN2 (0.57) | TDP1LMNAMGAMCA12CA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011135303-A2 | UBIQUITINATION MODULATORS | ITI SCOTLAND LIMITED (GB) | 2011-11-03 | — | — | WO | disclosed |