Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP11B1 | P15538 | 3/20 | 0.46 |
| ▸ | CYP11B2 | P19099 | 3/20 | 0.46 |
| ▸ | SLC2A1 | P11166 | 3/20 | 0.42 |
| ▸ | SLC2A3 | P11169 | 3/20 | 0.42 |
| ▸ | SLC2A4 | P14672 | 3/20 | 0.42 |
| ▸ | SLC2A2 | P11168 | 1/20 | 0.42 |
| ▸ | AR | P10275 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | ELANE | P08246 | 1/20 | 0.40 |
| ▸ | USP14 | P54578 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.39 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.39 |
| ▸ | HSP90B1 | P14625 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1218252 | 0.87 | SLC2A1 (0.41) | CYP11B1CYP11B2SLC2A1SLC2A3SLC2A4 | |
| SCHEMBL12898733 | 0.79 | CYP11B1 (0.42) | CYP11B1CYP11B2SLC2A1SLC2A3SLC2A4 | |
| SCHEMBL1218423 | 0.79 | CNR1 (0.49) | SLC2A1SLC2A3SLC2A4SLC2A2ABCB1 | |
| SCHEMBL1217759 | 0.77 | SLC2A1 (0.41) | SLC2A1SLC2A3SLC2A4SLC2A2ALDH1A1 | |
| SCHEMBL12885092 | 0.77 | SLC2A1 (0.41) | SLC2A1SLC2A3SLC2A4SLC2A2ALDH1A1 | |
| SCHEMBL1215113 | 0.76 | SLC2A1 (0.40) | SLC2A1SLC2A3SLC2A4SLC2A2ALDH1A1 | |
| SCHEMBL1218578 | 0.76 | SLC2A1 (0.43) | SLC2A1SLC2A3SLC2A4SLC2A2ABCB1 | |
| SCHEMBL12885580 | 0.76 | MEN1 (0.42) | SLC2A1SLC2A3SLC2A4SLC2A2ABCB1 | |
| SCHEMBL1218838 | 0.75 | PRKAA2 (0.41) | SLC2A1SLC2A3SLC2A4SLC2A2ABCB1 | |
| SCHEMBL12885326 | 0.75 | FPR1 (0.42) | SLC2A1SLC2A3SLC2A4SLC2A2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110028447-A1 | INDAZOLE DERIVATIVES | PFIZER INC. | 2011-02-03 | — | — | US | disclosed |
| US-20110028447-A1 | INDAZOLE DERIVATIVES | PFIZER INC. | 2011-02-03 | — | — | US | disclosed |
| EP-2265335-A1 | INDAZOLE DERIVATIVES | Pfizer Inc. (US) | 2010-12-29 | — | — | EP | disclosed |
| WO-2009106982-A1 | INDAZOLE DERIVATIVES | PFIZER INC. (US) | 2009-09-03 | — | — | WO | disclosed |
| WO-2009106982-A1 | INDAZOLE DERIVATIVES | PFIZER INC. (US) | 2009-09-03 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110028447-A1 | INDAZOLE DERIVATIVES | CNR1, CNR2, GPR119 | CYP11B1 149/4885CYP11B2 132/4885SLC2A1 4149/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.