Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CES2 | O00748 | 9/20 | 0.58 |
| ▸ | CES1 | P23141 | 8/20 | 0.58 |
| ▸ | TTR | P02766 | 4/20 | 0.56 |
| ▸ | RAB9A | P51151 | 2/20 | 0.50 |
| ▸ | NPC1 | O15118 | 1/20 | 0.50 |
| ▸ | BCAT1 | P54687 | 1/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | GLA | P06280 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | TNKS | O95271 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15071004 | 0.95 | TTR (0.59) | CES2CES1TTRRAB9ANPC1 | |
| SCHEMBL31619506 | 0.85 | ATM (0.57) | TTRRAB9ANPC1BCAT1MAPT | |
| SCHEMBL14124715 | 0.84 | TTR (0.59) | TTRRAB9ANPC1BCAT1KDM4E | |
| SCHEMBL6202281 | 0.80 | TTR (0.59) | TTRRAB9ANPC1BCAT1KDM4E | |
| SCHEMBL71110 | 0.79 | TTR (0.68) | TTRRAB9ANPC1BCAT1KDM4E | |
| SCHEMBL16448159 | 0.79 | TTR (0.58) | TTRRAB9ANPC1BCAT1KDM4E | |
| SCHEMBL16448160 | 0.79 | TTR (0.58) | TTRRAB9ANPC1BCAT1KDM4E | |
| SCHEMBL1222307 | 0.79 | TTR (0.78) | TTRRAB9ANPC1BCAT1KDM4E | |
| SCHEMBL15041013 | 0.77 | TTR (0.65) | TTRRAB9ANPC1KDM4EGLA | |
| SCHEMBL1195835 | 0.76 | CES2 (1.00) | CES2CES1RAB9ATSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20130165489-A1 | Small Molecule Modulators of HIV-1 Capsid Stability and Methods Thereof | THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (US) | 2013-06-27 | — | — | US | disclosed |
| US-20130165489-A1 | Small Molecule Modulators of HIV-1 Capsid Stability and Methods Thereof | THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (US) | 2013-06-27 | — | — | US | disclosed |
| WO-2011139637-A1 | SMALL-MOLECULE MODULATORS OF HIV-1 CAPSID STABILITY AND METHODS THEREOF | PHILADELPHIA HEALTH & EDUCATION CORPORATION (US) | 2011-11-10 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130165489-A1 | Small Molecule Modulators of HIV-1 Capsid Stability and Methods Thereof | ZC3HAV1, MAVS, HAVCR2 | CES2 1868/4885CES1 2428/4885TTR 4474/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.