Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 2/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
| ▸ | SSTR5 | P35346 | 5/20 | 0.49 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.45 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.45 |
| ▸ | OPRL1 | P41146 | 2/20 | 0.42 |
| ▸ | PARP1 | P09874 | 1/20 | 0.41 |
| ▸ | PARP2 | Q9UGN5 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.40 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.40 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.40 |
| ▸ | TEAD1 | P28347 | 1/20 | 0.40 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.40 |
| ▸ | EPAS1 | Q99814 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12184635 | 0.83 | GRM2 (0.48) | HSD11B1KDM4EALDH1A1SSTR5OPRL1 | |
| SCHEMBL12184446 | 0.77 | KMT2A (0.55) | KDM4ESSTR5TEAD1HIF1AEPAS1 | |
| SCHEMBL12184320 | 0.77 | KMT2A (0.55) | KDM4ESSTR5TEAD1HIF1AEPAS1 | |
| SCHEMBL12184342 | 0.77 | PRKAB2 (0.47) | SSTR5KCNH2HIF1AEPAS1 | |
| SCHEMBL12184354 | 0.76 | KDM4E (0.45) | KDM4EALDH1A1SSTR5OPRL1POLB | |
| SCHEMBL12184386 | 0.76 | SLC2A1 (0.42) | KDM4EALDH1A1SSTR5OPRL1POLB | |
| SCHEMBL12184344 | 0.75 | EPHX2 (0.47) | TEAD1 | |
| SCHEMBL12184753 | 0.75 | SLC2A1 (0.42) | KDM4EALDH1A1SSTR5OPRL1POLB | |
| SCHEMBL12185153 | 0.75 | ADRB2 (0.49) | HSD11B1ALDH1A1SSTR5GAAADRB2 | |
| SCHEMBL12184883 | 0.75 | BCHE (0.44) | SSTR5KCNH2ADRB2HIF1AEPAS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011142359-A1 | SPIRO COMPOUND AND DRUG FOR ACTIVATING ADIPONECTIN RECEPTOR | 日産化学工業株式会社 (JP) | 2011-11-17 | — | — | WO | disclosed |