Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.54 |
| ▸ | MEN1 | O00255 | 2/20 | 0.54 |
| ▸ | LMNA | P02545 | 1/20 | 0.54 |
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.51 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.49 |
| ▸ | ATG4B | Q9Y4P1 | 1/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.48 |
| ▸ | L3MBTL3 | Q96JM7 | 1/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.47 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 3/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | GNE | Q9Y223 | 1/20 | 0.43 |
| ▸ | GFER | P55789 | 1/20 | 0.42 |
| ▸ | BCHE | P06276 | 1/20 | 0.42 |
| ▸ | ACHE | P22303 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26772953 | 0.98 | HRH3 (0.53) | KMT2ASMN1; SMN2ALDH1A1MEN1LMNA | |
| SCHEMBL10329767 | 0.97 | SMN1; SMN2 (0.58) | KMT2ASMN1; SMN2ALDH1A1MEN1LMNA | |
| SCHEMBL24370438 | 0.88 | TDP1 (0.48) | KMT2ASMN1; SMN2ALDH1A1MEN1LMNA | |
| SCHEMBL20803928 | 0.87 | SCN9A (0.48) | KMT2ASMN1; SMN2ALDH1A1MEN1LMNA | |
| SCHEMBL19473337 | 0.87 | SMN1; SMN2 (0.65) | KMT2ASMN1; SMN2ALDH1A1MEN1LMNA | |
| SCHEMBL13466364 | 0.82 | PLA2G1B (0.45) | KMT2ASMN1; SMN2ALDH1A1MEN1LMNA | |
| SCHEMBL16131143 | 0.81 | NPC1 (0.44) | KMT2ASMN1; SMN2ALDH1A1MEN1LMNA | |
| SCHEMBL27398288 | 0.80 | PLA2G1B (0.45) | KMT2ASMN1; SMN2ALDH1A1MEN1LMNA | |
| SCHEMBL46306 | 0.79 | TDP1 (0.65) | SMN1; SMN2ALDH1A1HRH3L3MBTL1L3MBTL3 | |
| SCHEMBL30341672 | 0.79 | TDP1 (0.65) | SMN1; SMN2ALDH1A1HRH3L3MBTL1L3MBTL3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012142329-A1 | COMPOSITIONS AND THERAPEUTIC USES OF IKK-RELATED KINASE EPSILON AND TANKBINDING KINASE 1 INHIBITORS | MYREXIS, INC. (US) | 2012-10-18 | — | — | WO | disclosed |
| WO-2011146335-A1 | PIPERIDINYL-SUBSTITUTED LACTAMS AS GPR119 MODULATORS | ARRAY BIOPHARMA INC. (US) | 2011-11-24 | — | — | WO | disclosed |