Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLA2G1B | P04054 | 2/20 | 0.45 |
| ▸ | ATG4B | Q9Y4P1 | 2/20 | 0.45 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | GFER | P55789 | 2/20 | 0.38 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.38 |
| ▸ | ACACB | O00763 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | L3MBTL3 | Q96JM7 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | SCN9A | Q15858 | 3/20 | 0.37 |
| ▸ | SCN10A | Q9Y5Y9 | 2/20 | 0.37 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13466373 | 0.85 | PLA2G1B (0.47) | PLA2G1BATG4BPDE10ATDP1SMN1; SMN2 | |
| SCHEMBL16131134 | 0.82 | PLA2G1B (0.34) | PLA2G1BATG4BSMN1; SMN2LMNANPC1 | |
| SCHEMBL12186155 | 0.82 | KMT2A (0.54) | PLA2G1BATG4BTDP1SMN1; SMN2LMNA | |
| SCHEMBL10329767 | 0.82 | SMN1; SMN2 (0.58) | PLA2G1BATG4BTDP1SMN1; SMN2LMNA | |
| SCHEMBL26772953 | 0.81 | HRH3 (0.53) | PLA2G1BATG4BTDP1SMN1; SMN2LMNA | |
| SCHEMBL13467096 | 0.80 | PDE10A (0.56) | PDE10ATDP1SMN1; SMN2MAPTRAB9A | |
| SCHEMBL24370438 | 0.79 | TDP1 (0.48) | PLA2G1BATG4BTDP1SMN1; SMN2LMNA | |
| SCHEMBL19766587 | 0.79 | PLA2G1B (0.43) | PLA2G1BATG4BPDE10ATDP1SMN1; SMN2 | |
| SCHEMBL13466383 | 0.79 | PLA2G1B (0.43) | PLA2G1BATG4BTDP1SMN1; SMN2LMNA | |
| SCHEMBL20803928 | 0.78 | SCN9A (0.48) | PLA2G1BATG4BTDP1SMN1; SMN2LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018103688-A1 | IMIDAZO [1,5-A] PYRAZINE DERIVATIVES AS PI3Kdelta INHIBITORS | BEIGENE, LTD. (KY) | 2018-06-14 | — | — | WO | disclosed |
| WO-2012142329-A1 | COMPOSITIONS AND THERAPEUTIC USES OF IKK-RELATED KINASE EPSILON AND TANKBINDING KINASE 1 INHIBITORS | MYREXIS, INC. (US) | 2012-10-18 | — | — | WO | disclosed |