Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SERPINE1 | P05121 | 2/20 | 0.65 |
| ▸ | MEN1 | O00255 | 2/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.58 |
| ▸ | RAB9A | P51151 | 2/20 | 0.58 |
| ▸ | NPC1 | O15118 | 1/20 | 0.58 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.57 |
| ▸ | TMPRSS4 | Q9NRS4 | 1/20 | 0.57 |
| ▸ | GFER | P55789 | 1/20 | 0.56 |
| ▸ | MAPT | P10636 | 4/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.53 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.53 |
| ▸ | LMNA | P02545 | 1/20 | 0.53 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.53 |
| ▸ | P2RX1 | P51575 | 1/20 | 0.52 |
| ▸ | SMO | Q99835 | 1/20 | 0.51 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.51 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.51 |
| ▸ | GAA | P10253 | 1/20 | 0.51 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.51 |
| ▸ | GRIK1 | P39086 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5341743 | 0.87 | HDAC8 (0.62) | SERPINE1MEN1KMT2ARAB9ANPC1 | |
| SCHEMBL13812568 | 0.86 | TMPRSS4 (0.78) | SERPINE1MEN1KMT2ARAB9ANPC1 | |
| SCHEMBL16426276 | 0.86 | TMPRSS4 (0.64) | MEN1KMT2ARAB9ANPC1TMPRSS4 | |
| SCHEMBL12189648 | 0.86 | RAB9A (0.61) | SERPINE1MEN1KMT2ARAB9ANPC1 | |
| SCHEMBL12189469 | 0.86 | GRIK1 (0.67) | SERPINE1MEN1KMT2ARAB9ANPC1 | |
| SCHEMBL12189604 | 0.84 | GFER (0.75) | MEN1KMT2ARAB9ANPC1FFAR1 | |
| SCHEMBL12189680 | 0.82 | TMPRSS4 (0.56) | MEN1KMT2ARAB9ATMPRSS4MAPT | |
| SCHEMBL8770858 | 0.82 | FFAR1 (0.58) | MEN1KMT2ARAB9ANPC1FFAR1 | |
| SCHEMBL3787204 | 0.82 | TMPRSS4 (0.76) | MEN1KMT2ARAB9ANPC1TMPRSS4 | |
| SCHEMBL12189486 | 0.81 | GPR27 (0.59) | MEN1KMT2ATMPRSS4MAPTALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20150031663-A1 | PHTHALANILATE COMPOUNDS AND METHODS OF USE | UNIVERSITY OF NOTRE DAME DU LAC (US) | 2015-01-29 | — | — | US | disclosed |
| US-20120232150-A1 | PHTHALANILATE COMPOUNDS AND METHODS OF USE | University of Nortre Dame du Lac | 2012-09-13 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120232150-A1 | PHTHALANILATE COMPOUNDS AND METHODS OF USE | MPO, ALPI, NQO1 | SERPINE1 1737/4885MEN1 2365/4885KMT2A 1142/4885 |
| US-20150031663-A1 | PHTHALANILATE COMPOUNDS AND METHODS OF USE | MPO, ALPI, NQO1 | SERPINE1 1737/4885MEN1 2365/4885KMT2A 1142/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.