Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 7/20 | 0.57 |
| ▸ | GAA | P10253 | 1/20 | 0.56 |
| ▸ | SCN2A | Q99250 | 2/20 | 0.54 |
| ▸ | SCN10A | Q9Y5Y9 | 2/20 | 0.54 |
| ▸ | KDM1A | O60341 | 6/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.50 |
| ▸ | MMP13 | P45452 | 2/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.49 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.48 |
| ▸ | MMP2 | P08253 | 1/20 | 0.48 |
| ▸ | STAT3 | P40763 | 1/20 | 0.48 |
| ▸ | HTT | P42858 | 1/20 | 0.48 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12190918 | 0.90 | HDAC1 (0.69) | HDAC1GAASCN2ASCN10AKDM1A | |
| SCHEMBL12190916 | 0.86 | HDAC1 (0.70) | HDAC1GAASCN2ASCN10AKDM1A | |
| SCHEMBL12190914 | 0.82 | HDAC1 (0.56) | HDAC1SCN2ASCN10AKDM1ACYP3A4 | |
| SCHEMBL12190919 | 0.81 | SCN2A (0.56) | HDAC1SCN2ASCN10AKDM1ALMNA | |
| SCHEMBL12191068 | 0.80 | L3MBTL1 (0.64) | HDAC1GAASCN2ASCN10AKDM1A | |
| SCHEMBL12190843 | 0.80 | RAB9A (0.56) | HDAC1SCN2ASCN10ASMN1; SMN2LMNA | |
| SCHEMBL12190915 | 0.79 | TDP1 (0.54) | SCN2ASCN10ASMN1; SMN2MAPK1ALDH1A1 | |
| SCHEMBL12191147 | 0.78 | L3MBTL1 (0.68) | HDAC1SCN2ASCN10AKDM1ASMN1; SMN2 | |
| SCHEMBL12190893 | 0.77 | HDAC1 (0.78) | HDAC1SCN2ASCN10AKDM1A | |
| SCHEMBL12190995 | 0.76 | KMT2A (0.57) | HDAC1GAASCN2ASCN10AKDM1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8030336-B2 | Nicotinamide-based kinase inhibitors | YM BIOSCIENCES AUSTRALIA PTY LTD (AU) | 2011-10-04 | — | — | US | disclosed |
| US-8030336-B2 | Nicotinamide-based kinase inhibitors | YM BIOSCIENCES AUSTRALIA PTY LTD (AU) | 2011-10-04 | — | — | US | disclosed |
| US-20070060619-A1 | Nicotinamide-based kinase inhibitors | CYTOPIA PTY LTD (AU) | 2007-03-15 | — | — | US | disclosed |
| US-20070060619-A1 | Nicotinamide-based kinase inhibitors | CYTOPIA PTY LTD (AU) | 2007-03-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070060619-A1 | Nicotinamide-based kinase inhibitors | NADK, NAMPT, PDXK | HDAC1 147/4885GAA 607/4885SCN2A 1134/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.