Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK1 | Q13464 | 10/20 | 0.50 |
| ▸ | ROCK2 | O75116 | 11/20 | 0.48 |
| ▸ | CCR2 | P41597 | 3/20 | 0.45 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.42 |
| ▸ | MAOA | P21397 | 3/20 | 0.42 |
| ▸ | MAOB | P27338 | 3/20 | 0.42 |
| ▸ | HRH1 | P35367 | 2/20 | 0.42 |
| ▸ | CCR3 | P51677 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12193242 | 0.93 | ROCK1 (0.51) | ROCK1ROCK2CCR2KCNH2MAOA | |
| SCHEMBL12193244 | 0.91 | ROCK1 (0.52) | ROCK1ROCK2CCR2KCNH2MAOA | |
| SCHEMBL12193253 | 0.90 | ROCK1 (0.61) | ROCK1ROCK2CCR2KCNH2MAOA | |
| SCHEMBL12193268 | 0.88 | ROCK1 (0.54) | ROCK1ROCK2CCR2KCNH2HRH1 | |
| SCHEMBL12193264 | 0.88 | ROCK1 (0.49) | ROCK1ROCK2CCR2KCNH2MAOA | |
| SCHEMBL12193265 | 0.86 | ADRB2 (0.48) | ROCK1ROCK2CCR2KCNH2HRH1 | |
| SCHEMBL12193254 | 0.85 | EPHX2 (0.49) | ROCK1ROCK2CCR2 | |
| SCHEMBL12193215 | 0.84 | HRH3 (0.44) | ROCK1ROCK2CCR2KCNH2 | |
| SCHEMBL12193229 | 0.84 | HRH1 (0.44) | ROCK1ROCK2KCNH2HRH1CCR3 | |
| SCHEMBL12193245 | 0.84 | ROCK1 (0.49) | ROCK1ROCK2CCR2KCNH2HRH1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8722671-B2 | Isoquinoline derivatives | SANOFI (FR) | 2014-05-13 | — | — | US | disclosed |
| US-8722671-B2 | Isoquinoline derivatives | SANOFI (FR) | 2014-05-13 | — | — | US | disclosed |
| US-8501736-B2 | Isoquinoline derivatives | SANOFI (FR) | 2013-08-06 | — | — | US | disclosed |
| US-8501736-B2 | Isoquinoline derivatives | SANOFI (FR) | 2013-08-06 | — | — | US | disclosed |
| US-20110245248-A1 | ISOQUINOLINE DERIVATIVES | SANOFI-AVENTIS (FR) | 2011-10-06 | — | — | US | disclosed |
| US-20110245248-A1 | ISOQUINOLINE DERIVATIVES | SANOFI-AVENTIS (FR) | 2011-10-06 | — | — | US | disclosed |
| US-20090088429-A1 | Isoquinoline Derivatives | SANOFI-AVENTIS (FR) | 2009-04-02 | — | — | US | disclosed |
| US-20090088429-A1 | Isoquinoline Derivatives | SANOFI-AVENTIS (FR) | 2009-04-02 | — | — | US | disclosed |
| WO-2007000240-A1 | ISOQUINOLINE DERIVATIVES AS INHIBITORS OF RHO-KINASE | SANOFI-AVENTIS (DE) | 2007-01-04 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110245248-A1 | ISOQUINOLINE DERIVATIVES | MYLK2, MYLK, RHOT2 | ROCK1 7/4885ROCK2 5/4885CCR2 2845/4885 |
| US-20090088429-A1 | Isoquinoline Derivatives | MYLK2, MYLK, RHOT2 | ROCK1 7/4885ROCK2 5/4885CCR2 2845/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.