Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CNR2 | P34972 | 6/20 | 0.33 |
| ▸ | USP2 | O75604 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.32 |
| ▸ | KDM5A | P29375 | 1/20 | 0.32 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.30 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.30 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2006948 | 0.80 | USP2 (0.31) | USP2 | |
| SCHEMBL1159435 | 0.80 | MAPT (0.41) | CNR2TSHR | |
| SCHEMBL14930639 | 0.80 | USP2 (0.42) | CNR2USP2TSHRNFKB1CYP2C19 | |
| SCHEMBL1159175 | 0.78 | TSHR (0.38) | CNR2TSHRNFKB1CYP2C19KDM5A | |
| SCHEMBL27844146 | 0.75 | CNR2 (0.36) | CNR2TSHRNFKB1CYP2C19KDM5A | |
| SCHEMBL7874674 | 0.75 | FKBP1A (0.31) | — | |
| SCHEMBL8669400 | 0.75 | FKBP1A (0.33) | USP2 | |
| SCHEMBL6429489 | 0.75 | FKBP1A (0.31) | — | |
| SCHEMBL1355575 | 0.73 | TSHR (0.41) | CNR2TSHRNFKB1CYP2C19KDM5A | |
| SCHEMBL12155643 | 0.73 | TSHR (0.36) | CNR2TSHRNFKB1CYP2C19KDM5A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2252611-B1 | (DIHYDRO)PYRROLO[2,1-A]ISOQUINOLINES | ORGANON NV (NL) | 2011-10-05 | — | — | EP | disclosed |
| WO-2009098283-A1 | (DIHYDRO)PYRROLO[2,1-A]ISOQUINOLINES | N.V. ORGANON (NL) | 2009-08-13 | — | — | WO | disclosed |