Predicted protein targets (top 2)
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7874674 | 0.95 | FKBP1A (0.31) | — | |
| SCHEMBL6429489 | 0.95 | FKBP1A (0.31) | — | |
| SCHEMBL7245081 | 0.89 | FFAR3 (0.32) | FFAR3 | |
| SCHEMBL2683916 | 0.82 | USP2 (0.39) | USP2 | |
| Hydrochloric Acid SCHEMBL10884122 | 0.81 | USP2 (0.38) | USP2 | |
| SCHEMBL12193293 | 0.80 | CNR2 (0.33) | USP2 | |
| SCHEMBL7324549 | 0.80 | FFAR3 (0.33) | FFAR3 | |
| SCHEMBL8669400 | 0.78 | FKBP1A (0.33) | USP2 | |
| SCHEMBL3133271 | 0.77 | FFAR3 (0.37) | FFAR3 | |
| SCHEMBL15125244 | 0.77 | FFAR3 (0.37) | FFAR3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 29 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7960570-B2 | Small molecule inhibitors of rotamase enzyme activity | GLIAMED, INC. (US) | 2011-06-14 | — | — | US | claimed |
| US-20100145071-A1 | SMALL MOLECULE INHIBITORS OF ROTAMASE ENZYME ACTIVITY | GLIAMED, INC. (US) | 2010-06-10 | — | — | US | claimed |
| EP-1433781-B1 | Pyrrolidine carboxylic acid derivatives | MGI GP INC (US) | 2010-02-24 | — | — | EP | claimed |
| EP-1433781-A1 | Pyrrolidine carboxylic acid derivatives | GPI NIL Holdings, Inc. (US) | 2004-06-30 | — | — | EP | claimed |
| US-20110218343-A1 | SMALL MOLECULE INHIBITORS OF ROTAMASE ENZYME ACTIVITY | GLIAMED, INC. (US) | 2011-09-08 | — | — | US | disclosed |
| US-7960570-B2 | Small molecule inhibitors of rotamase enzyme activity | GLIAMED, INC. (US) | 2011-06-14 | — | — | US | disclosed |
| EP-1900726-A1 | Heterocyclic thioesters | MGI GP, Inc. (US) | 2008-03-19 | — | — | EP | disclosed |
| EP-1626043-A1 | Heterocyclic thioesters | MGI GP, Inc. (US) | 2006-02-15 | — | — | EP | disclosed |
| US-6984639-B2 | Heterocyclic ketone and thioester compounds and uses | GPI NIL HOLDINGS, INC. (US) | 2006-01-10 | — | — | US | disclosed |
| US-20050148637-A1 | Heterocyclic ketone and thioester compounds and uses | GPI NIL HOLDINGS, INC. | 2005-07-07 | — | — | US | disclosed |
| US-20050059693-A1 | Heterocyclic thioester and ketone hair growth compositions and uses | GPI NIL HOLDINGS, INC. | 2005-03-17 | — | — | US | disclosed |
| US-20040186098-A1 | Method for preventing and treating hearing loss using sensorineurotrophic compounds | AMGEN INC. | 2004-09-23 | — | — | US | disclosed |
| EP-1104299-A2 | N-LINKED UREA OR CARBAMATE OF HETEROCYCLIC THIOESTERS FOR VISION AND MEMORY DISORDERS | GPI NIL Holdings, Inc. (US) | 2001-06-06 | — | — | EP | disclosed |
| US-6218424-B1 | FOR EFFECTING NEURONAL ACTIVITIES IN ANIMALS, INCLUDING TREATING NEUROLOGICAL DISORDERS | GPI NIL HOLDINGS, INC. | 2001-04-17 | — | — | US | disclosed |
| EP-1082095-A1 | N-OXIDE OF HETEROCYCLIC ESTER, AMIDE, THIOESTER OR KETONE HAIR GROWTH COMPOSITIONS AND USES | GPI NIL Holdings, Inc. (US) | 2001-03-14 | — | — | EP | disclosed |
| WO-2000009484-A1 | PIPECOLIC ACID DERIVATIVES AND THEIR USE FOR VISION AND MEMORY DISORDERS | GPI NIL HOLDINGS, INC. (US) | 2000-02-24 | — | — | WO | disclosed |
| WO-2000009108-A2 | COMPOSITIONS AND USES FOR VISION AND MEMORY DISORDERS | GPI NIL HOLDINGS, INC. (US) | 2000-02-24 | — | — | WO | disclosed |
| WO-2000009110-A2 | N-LINKED UREA OR CARBAMATE OF HETEROCYCLIC THIOESTERS FOR VISION AND MEMORY DISORDERS | GPI NIL HOLDINGS INC. (US) | 2000-02-24 | — | — | WO | disclosed |
| WO-1999062486-A1 | N-OXIDE OF HETEROCYCLIC ESTER, AMIDE, THIOESTER, OR KETONE HAIR GROWTH COMPOSITIONS AND USES | GPI NIL HOLDINGS INC. (US) | 1999-12-09 | — | — | WO | disclosed |
| US-5990131-A | OF GIVEN FORMULA WHICH HAVE A HIGH AFFINITY FOR FKBPS (FK506 BINDING PROTEINS, A CLASS OF IMMUNOPHILINS) ARE POTENT ROTAMASE INHIBITORS AND EXHIBIT EXCELLENT NEUROTROPHIC EFFECTS; NO IMMUNOSUPPRESSIVE ACTIVITY | GPI NIL HOLDINGS INC. (US) | 1999-11-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040186098-A1 | Method for preventing and treating hearing loss using sensorineurotrophic compounds | GAP43, CHAT, MYOC | USP2 2966/4885FFAR3 3311/4885 |
| US-20100145071-A1 | SMALL MOLECULE INHIBITORS OF ROTAMASE ENZYME ACTIVITY | FKBP8, FKBP1A, FKBP2 | USP2 1111/4885FFAR3 4691/4885 |
| US-20050059693-A1 | Heterocyclic thioester and ketone hair growth compositions and uses | ACOT7, HSD17B7, ZDHHC7 | USP2 1545/4885FFAR3 497/4885 |
| US-20050148637-A1 | Heterocyclic ketone and thioester compounds and uses | BDNF, NTRK2, NTRK1 | USP2 2031/4885FFAR3 195/4885 |
| US-20110218343-A1 | SMALL MOLECULE INHIBITORS OF ROTAMASE ENZYME ACTIVITY | FKBP8, FKBP1A, FKBP2 | USP2 1111/4885FFAR3 4691/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.