Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRA1 | P14867 | 1/20 | 0.47 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.47 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 4/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.42 |
| ▸ | RAB9A | P51151 | 3/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 3/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | ACHE | P22303 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | CASP1 | P29466 | 1/20 | 0.41 |
| ▸ | JAK2 | O60674 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 2/20 | 0.40 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.39 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16738482 | 0.81 | HPGD (0.36) | RAB9ANPC1TSHRHPGD | |
| SCHEMBL16738523 | 0.79 | ALDH1A1 (0.35) | TDP1ALDH1A1RAB9ANPC1POLB | |
| SCHEMBL7822855 | 0.78 | GABRA1 (0.56) | GABRA1GABRG2GABRB3TDP1MAPT | |
| SCHEMBL7822858 | 0.78 | GABRA1 (0.56) | GABRA1GABRG2GABRB3TDP1MAPT | |
| SCHEMBL5597364 | 0.78 | TDP1 (0.53) | GABRA1GABRG2GABRB3TDP1MAPT | |
| SCHEMBL10627669 | 0.76 | GABRA1 (0.57) | GABRA1GABRG2GABRB3TDP1MAPT | |
| SCHEMBL10627662 | 0.76 | GABRA1 (0.57) | GABRA1GABRG2GABRB3TDP1MAPT | |
| SCHEMBL1407820 | 0.75 | GABRA1 (0.53) | GABRA1GABRG2GABRB3TDP1MAPT | |
| SCHEMBL1407819 | 0.75 | GABRA1 (0.53) | GABRA1GABRG2GABRB3TDP1MAPT | |
| SCHEMBL1284639 | 0.72 | MAPT (0.58) | TDP1MAPTALDH1A1SMN1; SMN2RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7893096-B2 | For example, N-methyl-4-[(2-{[2-(1-methylethyl)phenyl]amino}-1 H-benzimidazol-5-yl)oxy]pyridine-2-carboxamide; administering the compounds alone or in combination with another agent for the treatment of cancer, infectious diseases and/or allergies/asthma | NOVARTIS VACCINES AND DIAGNOSTICS, INC. (US) | 2011-02-22 | — | — | US | disclosed |