Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | APLNR | P35414 | 1/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
| ▸ | CA1 | P00915 | 2/20 | 0.44 |
| ▸ | CA2 | P00918 | 2/20 | 0.44 |
| ▸ | CA7 | P43166 | 1/20 | 0.44 |
| ▸ | CTSS | P25774 | 4/20 | 0.43 |
| ▸ | CTSK | P43235 | 4/20 | 0.43 |
| ▸ | CTSL | P07711 | 1/20 | 0.43 |
| ▸ | CTSB | P07858 | 1/20 | 0.43 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.41 |
| ▸ | SYK | P43405 | 1/20 | 0.40 |
| ▸ | SERPINE1 | P05121 | 1/20 | 0.40 |
| ▸ | MAOA | P21397 | 1/20 | 0.40 |
| ▸ | MAOB | P27338 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | PCSK9 | Q8NBP7 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29385609 | 1.00 | MEN1 (0.47) | MEN1GAAKMT2AAPLNRTDP1 | |
| SCHEMBL30464931 | 1.00 | MEN1 (0.47) | MEN1GAAKMT2AAPLNRTDP1 | |
| SCHEMBL10035060 | 0.86 | MEN1 (0.49) | MEN1GAAKMT2AAPLNRTDP1 | |
| SCHEMBL20355676 | 0.85 | MEN1 (0.45) | MEN1GAAKMT2AAPLNRTDP1 | |
| SCHEMBL1105702 | 0.83 | PCSK9 (0.50) | MEN1GAAKMT2AAPLNRTDP1 | |
| SCHEMBL6563149 | 0.83 | MEN1 (0.50) | MEN1GAAKMT2AAPLNRTDP1 | |
| SCHEMBL27686321 | 0.82 | MEN1 (0.46) | MEN1GAAKMT2AAPLNRTDP1 | |
| SCHEMBL26103224 | 0.82 | MEN1 (0.46) | MEN1GAAKMT2AAPLNRTDP1 | |
| SCHEMBL29027228 | 0.82 | APLNR (0.45) | MEN1GAAKMT2AAPLNRTDP1 | |
| SCHEMBL25760303 | 0.82 | APLNR (0.45) | MEN1GAAKMT2AAPLNRTDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230331719-A1 | Pyrazolopyridine Compounds and Methods of Inhibiting IRE1 Using Same | OPTIKIRA LLC (US) | 2023-10-19 | — | — | US | disclosed |
| US-20230331719-A1 | Pyrazolopyridine Compounds and Methods of Inhibiting IRE1 Using Same | OPTIKIRA LLC (US) | 2023-10-19 | — | — | US | disclosed |
| EP-4192462-A1 | PYRAZOLOPYRIDINE COMPOUNDS AND METHODS OF INHIBITING IRE1 USING SAME | Optikira LLC (US) | 2023-06-14 | — | — | EP | disclosed |
| WO-2022032078-A1 | PYRAZOLOPYRIDINE COMPOUNDS AND METHODS OF INHIBITING IRE1 USING SAME | Optikira, LLC (US) | 2022-02-10 | — | — | WO | disclosed |
| EP-2155762-B1 | PROCESS FOR THE SYNTHESIS OF ALKYL PHOSPHINIC ACIDS BY INITIATION OF AN AMINE AND AN AMINEOXIDE | ASTRAZENECA AB (SE) | 2011-10-12 | — | — | EP | disclosed |
| US-8026384-B2 | Process for the synthesis of alkyl phosphinic acids by initiation of an amine and an amineoxide | ASTRAZENECA AB (SE) | 2011-09-27 | — | — | US | disclosed |
| US-8026384-B2 | Process for the synthesis of alkyl phosphinic acids by initiation of an amine and an amineoxide | ASTRAZENECA AB (SE) | 2011-09-27 | — | — | US | disclosed |
| US-20100130773-A1 | PROCESS FOR THE SYNTHESIS OF ALKYL PHOSPHINIC ACIDS BY INITIATION OF AN AMINE AND AN AMINEOXIDE | ASTRAZENECA AB (SE) | 2010-05-27 | — | — | US | disclosed |
| US-20100130773-A1 | PROCESS FOR THE SYNTHESIS OF ALKYL PHOSPHINIC ACIDS BY INITIATION OF AN AMINE AND AN AMINEOXIDE | ASTRAZENECA AB (SE) | 2010-05-27 | — | — | US | disclosed |
| WO-2008136746-A1 | PROCESS FOR THE SYNTHESIS OF ALKYL PHOSPHINIC ACIDS BY INITIATION OF AN AMINE AND AN AMINEOXIDE | ASTRAZENECA AB (SE) | 2008-11-13 | — | — | WO | disclosed |
| WO-2008136745-A1 | PROCESS FOR THE SYNTHESIS OF ALKYL PHOSPHINIC ACIDS BY INITIATION OF AN AMINE AND AN AMINEOXIDE | ASTRAZENECA AB (SE) | 2008-11-13 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100130773-A1 | PROCESS FOR THE SYNTHESIS OF ALKYL PHOSPHINIC ACIDS BY INITIATION OF AN AMINE AND AN AMINEOXIDE | PPIP5K2, AGPS, PHPT1 | MEN1 291/4885GAA 1910/4885KMT2A 768/4885 |
| US-20230331719-A1 | Pyrazolopyridine Compounds and Methods of Inhibiting IRE1 Using Same | XBP1, ERN1, ERN2 | MEN1 3460/4885GAA 1664/4885KMT2A 3798/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.