Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.56 |
| ▸ | LMNA | P02545 | 1/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.38 |
| ▸ | FBP1 | P09467 | 1/20 | 0.36 |
| ▸ | ATIC | P31939 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | IKBKB | O14920 | 2/20 | 0.33 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | BLM | P54132 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24389364 | 0.80 | ALDH1A1 (0.58) | ALDH1A1LMNAKDM4ETDP1TP53 | |
| SCHEMBL24113793 | 0.78 | ALDH1A1 (0.56) | ALDH1A1LMNAKDM4ETDP1TP53 | |
| SCHEMBL2112227 | 0.77 | ALDH1A1 (0.59) | ALDH1A1LMNAKDM4ETDP1TP53 | |
| SCHEMBL22108809 | 0.77 | ALDH1A1 (0.55) | ALDH1A1LMNAKDM4ETDP1TP53 | |
| SCHEMBL6304946 | 0.75 | ALDH1A1 (0.53) | ALDH1A1LMNAKDM4ETDP1TP53 | |
| SCHEMBL12081642 | 0.74 | ALDH1A1 (0.56) | ALDH1A1LMNAKDM4ETDP1TP53 | |
| SCHEMBL6691811 | 0.72 | ALDH1A1 (0.54) | ALDH1A1LMNAKDM4ETDP1TP53 | |
| SCHEMBL13618229 | 0.72 | LMNA (1.00) | ALDH1A1LMNAKDM4ETDP1TP53 | |
| SCHEMBL3452770 | 0.72 | ALDH1A1 (0.54) | ALDH1A1LMNAKDM4ETDP1TP53 | |
| SCHEMBL6304030 | 0.71 | ALDH1A1 (0.49) | ALDH1A1LMNAKDM4ETDP1TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2066672-B1 | AN IMPROVED PROCESS FOR THE PREPARATION OF TEMOZOLOMIDE AND ANALOGS | CIPLA LTD (IN) | 2015-06-24 | — | — | EP | disclosed |
| EP-2374807-A2 | An improved process for the isolation of temozolomide | CIPLA LIMITED (IN) | 2011-10-12 | — | — | EP | disclosed |