Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DHPS | P49366 | 1/20 | 0.43 |
| ▸ | CCNB2 | O95067 | 2/20 | 0.42 |
| ▸ | CDK1 | P06493 | 2/20 | 0.42 |
| ▸ | CCNB1 | P14635 | 2/20 | 0.42 |
| ▸ | GSK3B | P49841 | 2/20 | 0.42 |
| ▸ | CCNB3 | Q8WWL7 | 2/20 | 0.42 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.42 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13638414 | 0.77 | ALDH1A1 (0.41) | ALDH1A1KDM4EMAPTCYP2C9CYP2C19 | |
| SCHEMBL837314 | 0.74 | ALOX5 (0.43) | ALDH1A1HPGDHSD17B10DRD2CA12 | |
| SCHEMBL9251499 | 0.73 | ALDH1A1 (0.40) | ALDH1A1KDM4EMAPTCYP2C9CYP2C19 | |
| SCHEMBL9251495 | 0.73 | ALDH1A1 (0.40) | ALDH1A1KDM4EMAPTCYP2C9CYP2C19 | |
| SCHEMBL13930334 | 0.73 | DRD2 (0.46) | DHPSCCNB2CDK1CCNB1GSK3B | |
| SCHEMBL30609062 | 0.73 | DRD2 (0.46) | DHPSCCNB2CDK1CCNB1GSK3B | |
| SCHEMBL5362141 | 0.73 | CCNB2 (0.48) | DHPSCCNB2CDK1CCNB1GSK3B | |
| SCHEMBL10438847 | 0.72 | ALDH1A1 (0.58) | ALDH1A1KDM4EMAPTCYP2C9CYP2C19 | |
| SCHEMBL69522 | 0.72 | ALDH1A1 (0.58) | ALDH1A1KDM4EMAPTCYP2C9CYP2C19 | |
| SCHEMBL29612197 | 0.71 | AHR (0.44) | DHPSCCNB2CDK1CCNB1GSK3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8748601-B2 | Selective serine/threonine kinase inhibitors | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2014-06-10 | — | — | US | disclosed |
| US-8748601-B2 | Selective serine/threonine kinase inhibitors | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2014-06-10 | — | — | US | disclosed |
| US-8034821-B2 | Selective serine/threonine kinase inhibitors | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2011-10-11 | — | — | US | disclosed |
| US-8034821-B2 | Selective serine/threonine kinase inhibitors | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2011-10-11 | — | — | US | disclosed |
| US-20100256171-A1 | SELECTIVE SERINE/THREONINE KINASE INHIBITORS | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2010-10-07 | — | — | US | disclosed |
| US-20100256171-A1 | SELECTIVE SERINE/THREONINE KINASE INHIBITORS | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2010-10-07 | — | — | US | disclosed |
| US-7687506-B2 | Selective serine/threonine kinase inhibitors | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2010-03-30 | — | — | US | disclosed |
| US-7687506-B2 | Selective serine/threonine kinase inhibitors | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2010-03-30 | — | — | US | disclosed |
| US-20090221614-A1 | SELECTIVE SERINE/THREONINE KINASE INHIBITORS | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (CA) | 2009-09-03 | — | — | US | disclosed |
| US-20090221614-A1 | SELECTIVE SERINE/THREONINE KINASE INHIBITORS | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (CA) | 2009-09-03 | — | — | US | disclosed |
| US-20070082884-A1 | Selective serine/threonine kinase inhibitors | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2007-04-12 | — | — | US | disclosed |
| US-20070082884-A1 | Selective serine/threonine kinase inhibitors | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2007-04-12 | — | — | US | disclosed |
| WO-2007038613-A2 | SELECTIVE SERINE/THREONINE KINASE INHIBITORS | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2007-04-05 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070082884-A1 | Selective serine/threonine kinase inhibitors | DSTYK, TTK, SBK1 | DHPS 2531/4885CCNB2 1636/4885CDK1 158/4885 |
| US-20090221614-A1 | SELECTIVE SERINE/THREONINE KINASE INHIBITORS | DSTYK, TTK, SBK1 | DHPS 2531/4885CCNB2 1636/4885CDK1 158/4885 |
| US-20100256171-A1 | SELECTIVE SERINE/THREONINE KINASE INHIBITORS | DSTYK, TTK, SBK1 | DHPS 2531/4885CCNB2 1636/4885CDK1 158/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.