⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bromide SCHEMBL11508917 | 0.74 | HSP90AA1 (0.35) | — | |
| Bromide SCHEMBL11510071 | 0.74 | HSP90AA1 (0.35) | — | |
| SCHEMBL4245299 | 0.73 | HSP90AA1 (0.35) | — | |
| SCHEMBL18917295 | 0.65 | KDM4E (0.48) | — | |
| SCHEMBL28922481 | 0.64 | — | — | |
| SCHEMBL12235919 | 0.62 | — | — | |
| SCHEMBL12706333 | 0.61 | — | — | |
| SCHEMBL17131854 | 0.61 | ALDH1A1 (0.31) | — | |
| SCHEMBL10046205 | 0.61 | — | — | |
| SCHEMBL12159902 | 0.61 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20150159153-A1 | METHOD FOR TRANSFECTION OF NUCLEIC ACIDS INTO EUKARYOTIC CELLS IN 3D SCAFFOLD | COMMISSARIAT A L'ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES (FR) | 2015-06-11 | — | — | US | disclosed |
| US-8034959-B2 | Methods of treating cancer with an antibody-drug conjugate | MEDAREX, INC. (US) | 2011-10-11 | — | — | US | disclosed |
| US-7977465-B2 | Peptidyl prodrugs and linkers and stabilizers useful therefor | MEDAREX, INC. (US) | 2011-07-12 | — | — | US | disclosed |
| US-20090209734-A1 | PEPTIDYL PRODRUGS AND LINKERS AND STABILIZERS USEFUL THEREFOR | MEDAREX, INC. (US) | 2009-08-20 | — | — | US | disclosed |
| US-20090175888-A1 | METHODS OF TREATING CANCER WITH AN ANTIBODY-DRUG CONJUGATE | MEDAREX, INC. (US) | 2009-07-09 | — | — | US | disclosed |