Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK1 | P23458 | 5/20 | 0.44 |
| ▸ | JAK2 | O60674 | 3/20 | 0.44 |
| ▸ | TYK2 | P29597 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | PKM | P14618 | 1/20 | 0.43 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.42 |
| ▸ | SYK | P43405 | 1/20 | 0.42 |
| ▸ | IDO1 | P14902 | 1/20 | 0.42 |
| ▸ | TDO2 | P48775 | 1/20 | 0.42 |
| ▸ | BCDIN3D | Q7Z5W3 | 1/20 | 0.41 |
| ▸ | TGFBR1 | P36897 | 2/20 | 0.41 |
| ▸ | BRD4 | O60885 | 1/20 | 0.40 |
| ▸ | GPR119 | Q8TDV5 | 4/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.40 |
| ▸ | JAK3 | P52333 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12205335 | 0.83 | KDM4E (0.55) | KDM4EPKMSYKIDO1TDO2 | |
| SCHEMBL12225151 | 0.82 | BRD3 (0.45) | JAK1KDM4EPKMPRMT5SYK | |
| SCHEMBL12247504 | 0.80 | KDM4E (0.51) | KDM4EPKMSYKIDO1TDO2 | |
| SCHEMBL12205201 | 0.78 | TGFBR1 (0.56) | KDM4EPKMSYKTGFBR1GPR119 | |
| SCHEMBL15206132 | 0.77 | IDO1 (0.53) | KDM4EPKMSYKIDO1TDO2 | |
| SCHEMBL12131873 | 0.76 | JAK1 (0.55) | JAK1JAK2TYK2PRMT5SYK | |
| SCHEMBL4933145 | 0.76 | GPR119 (0.51) | KDM4EPKMTGFBR1GPR119CYP3A4 | |
| SCHEMBL12225168 | 0.74 | IDO1 (0.42) | JAK1JAK2TYK2KDM4EPKM | |
| SCHEMBL6148442 | 0.73 | CYP2D6 (0.64) | KDM4EPKMTGFBR1GPR119CYP3A4 | |
| SCHEMBL29762671 | 0.71 | JAK1 (0.54) | JAK1JAK2TYK2KDM4EPRMT5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2377860-A1 | Novel compounds for the treatment of diseases associated with amyloid or amyloid-like proteins | AC Immune S.A. (CH) | 2011-10-19 | — | — | EP | disclosed |