Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TGFBR1 | P36897 | 3/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | PKM | P14618 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | RORC | P51449 | 1/20 | 0.48 |
| ▸ | GPR119 | Q8TDV5 | 9/20 | 0.47 |
| ▸ | SYK | P43405 | 1/20 | 0.47 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.44 |
| ▸ | STS | P08842 | 1/20 | 0.43 |
| ▸ | CRHR1 | P34998 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12205335 | 0.87 | KDM4E (0.55) | TGFBR1KDM4EPKMGPR119SYK | |
| SCHEMBL12247504 | 0.83 | KDM4E (0.51) | TGFBR1KDM4EPKMGPR119SYK | |
| SCHEMBL4933145 | 0.81 | GPR119 (0.51) | TGFBR1KDM4EPKMGPR119 | |
| SCHEMBL15206132 | 0.80 | IDO1 (0.53) | TGFBR1KDM4EPKMGPR119SYK | |
| SCHEMBL6148442 | 0.79 | CYP2D6 (0.64) | TGFBR1KDM4EPKMMAPTGPR119 | |
| SCHEMBL12205348 | 0.78 | JAK1 (0.44) | TGFBR1KDM4EPKMGPR119SYK | |
| SCHEMBL12245529 | 0.78 | CHRNB4 (0.47) | CRHR1 | |
| SCHEMBL12225168 | 0.77 | IDO1 (0.42) | TGFBR1KDM4EPKMGPR119SYK | |
| SCHEMBL12205243 | 0.76 | CHRNB4 (0.48) | CRHR1 | |
| SCHEMBL5548652 | 0.75 | TGFBR1 (0.53) | TGFBR1KDM4EPKMMAPTRORC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2377860-A1 | Novel compounds for the treatment of diseases associated with amyloid or amyloid-like proteins | AC Immune S.A. (CH) | 2011-10-19 | — | — | EP | disclosed |