Known targets — ChEMBL curated mechanism
ACEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2BTKCACNA1CCACNA1DCACNA1FCACNA1SCCR5CPT1BCPT2DPP4DRD1DRD2EGFRERBB2ERBB4HRH1HRH3HTR1AHTR2AHTR2BHTR2CHTR4JAK1JAK2JAK3MPLMTORPPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PPARGSLC6A2SLC6A3SLC6A4SMOTYK2pol
The experimentally established mechanism targets of Maleic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 4/20 | 0.90 |
| ▸ | TP53 | P04637 | 1/20 | 0.90 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.90 |
| ▸ | EGLN3 | Q9H6Z9 | 1/20 | 0.90 |
| ▸ | HCAR2 | Q8TDS4 | 4/20 | 0.50 |
| ▸ | GABRR1 | P24046 | 2/20 | 0.44 |
| ▸ | GABRR2 | P28476 | 2/20 | 0.44 |
| ▸ | BLM | P54132 | 2/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.44 |
| ▸ | GABRR3 | A8MPY1 | 1/20 | 0.44 |
| ▸ | APEX1 | P27695 | 1/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.43 |
| ▸ | RECQL | P46063 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Maleic Acid SCHEMBL52799 | 1.00 | — | — | |
| Fumaric Acid SCHEMBL453820 | 1.00 | TSHR (0.90) | TSHRTP53EGLN1EGLN3HCAR2 | |
| Fumaric Acid SCHEMBL28080180 | 1.00 | TSHR (0.90) | TSHRTP53EGLN1EGLN3HCAR2 | |
| Fumaric Acid SCHEMBL4816794 | 1.00 | TSHR (0.90) | TSHRTP53EGLN1EGLN3HCAR2 | |
| Fumaric Acid SCHEMBL52800 | 1.00 | — | — | |
| Maleic Acid SCHEMBL4816790 | 1.00 | TSHR (0.90) | TSHRTP53EGLN1EGLN3HCAR2 | |
| Fumaric Acid SCHEMBL6468133 | 1.00 | TSHR (0.90) | TSHRTP53EGLN1EGLN3HCAR2 | |
| Fumaric Acid SCHEMBL106605 | 1.00 | — | — | |
| Maleic Acid SCHEMBL7102604 | 0.95 | TSHR (0.82) | TSHRTP53EGLN1EGLN3HCAR2 | |
| Maleic Acid SCHEMBL3410757 | 0.95 | TSHR (0.82) | TSHRTP53EGLN1EGLN3HCAR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1442 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4704582-A1 | DEPHOSPHORYLATION OF SKIM MILK, ULTRA-FILTERED MILK OR MICELLAR CASEIN ISOLATE | N.V. Nutricia (NL) | 2026-03-11 | — | — | EP | claimed |
| US-20260053157-A1 | Dephosphorylation of skim milk, ultra-filtered milk or micellar casein isolate | N.V. NUTRICIA (NL) | 2026-02-26 | — | — | US | claimed |
| EP-4691771-A1 | LAMINATE AND LAMINATE PRODUCTION METHOD | Zeon Corporation (JP) | 2026-02-11 | — | — | EP | claimed |
| EP-4616027-A1 | IMPROVED SCALE INHIBITION FOR PULP DIGESTERS | Ecolab USA Inc. (US) | 2025-09-17 | — | — | EP | claimed |
| WO-2025056484-A1 | SOAP BARS COMPRISING HIGH SOLUBLE SOAP CONTENT | UNILEVER IP HOLDINGS B.V. (NL) | 2025-03-20 | — | — | WO | claimed |
| WO-2025056296-A1 | SOAP BARS COMPRISING POTASSIUM SOAP | UNILEVER IP HOLDINGS B.V. (NL) | 2025-03-20 | — | — | WO | claimed |
| CN-116589314-B | Amino acid organic fertilizer and preparation method thereof | 江西正合生态农业有限公司 | 2025-02-18 | — | — | CN | claimed |
| CN-115893369-B | Hard carbon negative electrode material, preparation method thereof, mixed negative electrode material and secondary battery | 赣州立探新能源科技有限公司 | 2025-01-28 | — | — | CN | claimed |
| CN-119185171-A | Adhesive microneedle patch for plugging tracheal fistula and preparation method thereof | 上海市肺科医院（上海市职业病防治院） | 2024-12-27 | — | — | CN | claimed |
| CN-118924701-A | TAT-PEG-PLGA coated manganese doped silicon dioxide drug-loaded nanoparticle and preparation and application thereof | 广州医科大学附属番禺中心医院(广州市番禺区中心医院、广州市番禺区人民医院) | 2024-11-12 | — | — | CN | claimed |
| CN-1037171-A | Improved temperature control process for the preparation of 2, 2-oxodisuccinates as laundry detergent builders | PROCTER & GAMBLE (US) | 1989-11-15 | — | — | CN | claimed |
| US-4861677-A | ETHYLENE-VINYLACETATE COPOLYMER BLEND, GRAFT POLYMER | E. I. DU PONT DE NEMOURS AND COMPANY (US) | 1989-08-29 | — | — | US | claimed |
| US-4861676-A | Improved coextrudable adhesive and products therefrom | E. I. DU PONT DE NEMOURS AND COMPANY (US) | 1989-08-29 | — | — | US | claimed |
| EP-0320213-A2 | Improved, controlled temperature process for making 2,2'-oxodisuccinates useful as laundry detergent builders | THE PROCTER & GAMBLE COMPANY (US) | 1989-06-14 | — | — | EP | claimed |
| US-4798907-A | Controlled temperature process for making 2,2'-oxodisuccinates useful as laundry detergent builders | THE PROCTER & GAMBLE COMPANY (US) | 1989-01-17 | — | — | US | claimed |
| US-4472447-A | 5'-NUCLEOTIDE, ALKALI SALT OF ORGANIC ACID | AJINOMOTO CO., INC. (JP) | 1984-09-18 | — | — | US | claimed |
| EP-0031162-B1 | MIXED SEASONING ON BASIS OF MONOSODIUM L-GLUTAMATE | AJINOMOTO CO., INC. (JP) | 1983-10-12 | — | — | EP | claimed |
| EP-0031162-A1 | Mixed seasoning on basis of monosodium L-glutamate | AJINOMOTO CO., INC. (JP) | 1981-07-01 | — | — | EP | claimed |
| US-4258072-A | MSG, A 5'-NUCLEOTIDE, SUCCINIC ACID OR SODIUM SUCCINATE, SALT OF AN ORGANIC ACID | AJINOMOTO CO., INC. (JP) | 1981-03-24 | — | — | US | claimed |
| US-4147647-A | DISSOLVING GYPSUM USING AN ALKALI METAL MALEATE SALT | PETROLITE CORPORATION (US) | 1979-04-03 | — | — | US | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20260053157-A1 | Dephosphorylation of skim milk, ultra-filtered milk or micellar casein isolate | PSPH, PPM1A, PPM1G | TSHR 2214/4885TP53 492/4885EGLN1 4087/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.