Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LTA4H | P09960 | 1/20 | 0.57 |
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.42 |
| ▸ | GRM2 | Q14416 | 3/20 | 0.42 |
| ▸ | FAAH | O00519 | 1/20 | 0.42 |
| ▸ | MGLL | Q99685 | 1/20 | 0.42 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.41 |
| ▸ | GBA1 | P04062 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | CNR2 | P34972 | 1/20 | 0.40 |
| ▸ | CCNC | P24863 | 1/20 | 0.40 |
| ▸ | CDK8 | P49336 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14960477 | 1.00 | LTA4H (0.57) | LTA4HHRH3ALDH1A1GRM2FAAH | |
| SCHEMBL8805178 | 0.86 | LTA4H (0.56) | LTA4HHRH3ALDH1A1GRM2PDE1B | |
| SCHEMBL30308375 | 0.86 | LTA4H (0.56) | LTA4HHRH3ALDH1A1GRM2PDE1B | |
| SCHEMBL30508309 | 0.86 | LTA4H (0.56) | LTA4HHRH3ALDH1A1GRM2PDE1B | |
| SCHEMBL30460552 | 0.86 | LTA4H (0.56) | LTA4HHRH3ALDH1A1GRM2PDE1B | |
| SCHEMBL1189298 | 0.85 | LTA4H (0.62) | LTA4HCNR2 | |
| SCHEMBL1005882 | 0.85 | LTA4H (0.62) | LTA4HCNR2 | |
| SCHEMBL1005883 | 0.85 | LTA4H (0.62) | LTA4HCNR2 | |
| SCHEMBL22011076 | 0.83 | LTA4H (0.54) | LTA4HHRH3ALDH1A1GRM2PDE1B | |
| SCHEMBL696684 | 0.83 | SMN1; SMN2 (0.59) | LTA4HHRH3ALDH1A1PDE1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2499146-B1 | TRICYCLIC PYRAZOL AMINE DERIVATIVES | MERCK SERONO SA (CH) | 2016-09-21 | — | — | EP | disclosed |
| WO-2011058149-A1 | TRICYCLIC PYRAZOL AMINE DERIVATIVES | MERCK SERONO S.A. (CH) | 2011-05-19 | — | — | WO | disclosed |