Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LTA4H | P09960 | 1/20 | 0.54 |
| ▸ | GRM2 | Q14416 | 3/20 | 0.40 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.40 |
| ▸ | ATM | Q13315 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | DRD4 | P21917 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.39 |
| ▸ | CCNC | P24863 | 1/20 | 0.39 |
| ▸ | CDK8 | P49336 | 1/20 | 0.39 |
| ▸ | CNR2 | P34972 | 1/20 | 0.39 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.38 |
| ▸ | PIK3R2 | O00459 | 1/20 | 0.38 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.38 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.38 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.38 |
| ▸ | PIK3R5 | Q8WYR1 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12214 | 0.83 | LTA4H (0.57) | LTA4HGRM2PDE1BKDM4EALDH1A1 | |
| SCHEMBL14960477 | 0.83 | LTA4H (0.57) | LTA4HGRM2PDE1BKDM4EALDH1A1 | |
| SCHEMBL30508309 | 0.82 | LTA4H (0.56) | LTA4HGRM2PDE1BSMN1; SMN2KDM4E | |
| SCHEMBL8805178 | 0.82 | LTA4H (0.56) | LTA4HGRM2PDE1BKDM4EALDH1A1 | |
| SCHEMBL30308375 | 0.82 | LTA4H (0.56) | LTA4HGRM2PDE1BKDM4EALDH1A1 | |
| SCHEMBL30460552 | 0.82 | LTA4H (0.56) | LTA4HGRM2PDE1BKDM4EALDH1A1 | |
| SCHEMBL1005882 | 0.81 | LTA4H (0.62) | LTA4HCNR2PIK3CDPIK3R2PIK3CA | |
| SCHEMBL1005883 | 0.81 | LTA4H (0.62) | LTA4HCNR2PIK3CDPIK3R2PIK3CA | |
| SCHEMBL1189298 | 0.81 | LTA4H (0.62) | LTA4HCNR2PIK3CDPIK3R2PIK3CA | |
| SCHEMBL3509984 | 0.79 | SMN1; SMN2 (0.59) | LTA4HPDE1BSMN1; SMN2MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10660897-B2 | C5aR antagonists | CHEMOCENTRYX, INC. (US) | 2020-05-26 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10660897-B2 | C5aR antagonists | C5AR1, C5AR2, C3AR1 | LTA4H 104/4885GRM2 1925/4885PDE1B 3050/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.