SCHEMBL12216738

SCHEMBL12216738

O=C1O[C@H](C(O)CO)[C@H](O)C1O

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 12)

geneUniProtsupporting neighboursconfidence
▸ LMNA P02545 3/20 1.00
▸ HIF1A Q16665 2/20 1.00
▸ MANBA O00462 1/20 1.00
▸ THRB P10828 1/20 1.00
▸ CYP2C19 P33261 1/20 0.64
▸ DNMT1 P26358 1/20 0.56
▸ CTDSP1 Q9GZU7 1/20 0.56
▸ IDUA P35475 1/20 0.56
▸ GUSB P08236 1/20 0.56
▸ GBA1 P04062 1/20 0.47
▸ MAPT P10636 1/20 0.39
▸ L3MBTL1 Q9Y468 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL14391479 1.00 LMNA (1.00) LMNAHIF1AMANBATHRBCYP2C19
SCHEMBL16687559 1.00 LMNA (1.00) LMNAHIF1AMANBATHRBCYP2C19
SCHEMBL14296856 1.00 LMNA (1.00) LMNAHIF1AMANBATHRBCYP2C19
SCHEMBL25070350 1.00 LMNA (1.00) LMNAHIF1AMANBATHRBCYP2C19
SCHEMBL19638526 1.00 LMNA (1.00) LMNAHIF1AMANBATHRBCYP2C19
SCHEMBL23111379 1.00 LMNA (1.00) LMNAHIF1AMANBATHRBCYP2C19
SCHEMBL8079451 1.00 LMNA (1.00) LMNAHIF1AMANBATHRBCYP2C19
SCHEMBL23532013 1.00 LMNA (1.00) LMNAHIF1AMANBATHRBCYP2C19
SCHEMBL1893475 1.00 LMNA (1.00) LMNAHIF1AMANBATHRBCYP2C19
SCHEMBL17017514 1.00 LMNA (1.00) LMNAHIF1AMANBATHRBCYP2C19

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8329413-B2 Glycoproteomic probes for fluorescent imaging of fucosylated glycans in vivo ACADEMIA SINICA (TW) 2012-12-11 — — US disclosed
US-20110257376-A1 GLYCOPROTEOMIC PROBES FOR FLUORESCENT IMAGING OF FUCOSYLATED GLYCANS IN VIVO ACADEMIA SINICA (TW) 2011-10-20 — — US disclosed
US-7910319-B2 Incubating azido-derivatized fucose analog in cell to form azido-derivatized glycoconjugate which is contacted with probe, based on copper-catalyzed cycloaddition of probe comprising alkynyl group; fucosyltransferases; microscopy ACADEMIA SINICA (TW) 2011-03-22 — — US disclosed
US-20080241856-A1 Glycoproteomic probes for fluorescent imaging of fucosylated glycans in vivo ACADEMIA SINICA (TW) 2008-10-02 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20110257376-A1 GLYCOPROTEOMIC PROBES FOR FLUORESCENT IMAGING OF FUCOSYLATED GLYCANS IN VIVO FUCA2, FUCA1, FUT6 LMNA 2671/4885HIF1A 4072/4885MANBA 39/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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