Water

Water

SCHEMBL122257

CS(=O)(=O)[O-].O.O.[Na+]

nearest known ligand 0.00

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Known targets — ChEMBL curated mechanism

ABL1ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB2AGTR1BCL2BCL2A1BCL2L1BCL2L10BCL2L2BCRBRAFCHRM1CHRNA10CHRNA9DRD1DRD2DRD3DRD4DRD5EGFRF2FLT1FLT4GCKGHSRGNRHRGRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BHTR1AHTR1BHTR1DHTR2AHTR2CHTR3AIDH2KDRKITMAOBMCL1MTTPPP4HBPDGFRBPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PIKFYVEROCK1ROCK2SLC18A2SLC6A2SLC6A3SLC6A4TACR1TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8gyrAgyrBparCparEpol

The experimentally established mechanism targets of Water. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Water SCHEMBL16716815 1.00
SCHEMBL6928129 0.95 TSHR (0.50)
SCHEMBL16034529 0.95 TSHR (0.50)
SCHEMBL34839 0.95
SCHEMBL3361189 0.90
Potassium Ion SCHEMBL8720018 0.90 TSHR (0.46)
Water SCHEMBL22581620 0.90 KDM4E (0.46)
Fluoride SCHEMBL22288153 0.90
Water SCHEMBL22581608 0.90 KDM4E (0.46)
Water SCHEMBL28765202 0.90

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2213674-B1 PURIFICATION METHOD OF PEMETREXED SALTS,SODIUM SALTS AND DISODIUM SALTS CHONGQING PHARM RES INST CO (CN) 2012-03-07 EP claimed
US-20100305319-A1 METHOD OF PURIFYING A SALT, SODIUM SALT AND DISODIUM SALT OF PEMETREXED Chongquing Pharmaceutical Research Institute Co. ltd (CN) 2010-12-02 US claimed
EP-2213674-A1 PURIFICATION METHOD OF PEMETREXED SALTS,SODIUM SALTS AND DISODIUM SALTS Chongqing Pharmaceutical Research Institute Co., Ltd. (CN) 2010-08-04 EP claimed
EP-2213674-B1 PURIFICATION METHOD OF PEMETREXED SALTS,SODIUM SALTS AND DISODIUM SALTS CHONGQING PHARM RES INST CO (CN) 2012-03-07 EP disclosed
US-20100305319-A1 METHOD OF PURIFYING A SALT, SODIUM SALT AND DISODIUM SALT OF PEMETREXED Chongquing Pharmaceutical Research Institute Co. ltd (CN) 2010-12-02 US disclosed
EP-2213674-A1 PURIFICATION METHOD OF PEMETREXED SALTS,SODIUM SALTS AND DISODIUM SALTS Chongqing Pharmaceutical Research Institute Co., Ltd. (CN) 2010-08-04 EP disclosed