Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADAMTS5 | Q9UNA0 | 4/20 | 0.44 |
| ▸ | MMP2 | P08253 | 2/20 | 0.44 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12232812 | 0.92 | ADAMTS5 (0.46) | ADAMTS5MMP2 | |
| SCHEMBL12232681 | 0.92 | MMP2 (0.42) | ADAMTS5MMP2 | |
| SCHEMBL12232279 | 0.90 | GRIN2D (0.44) | ADAMTS5MMP2 | |
| SCHEMBL12232282 | 0.87 | MMP2 (0.42) | ADAMTS5MMP2 | |
| SCHEMBL12233006 | 0.87 | LRRK2 (0.38) | — | |
| SCHEMBL12232680 | 0.86 | ADAMTS5 (0.49) | ADAMTS5MMP2ADAM17 | |
| SCHEMBL12233003 | 0.86 | CHRM2 (0.47) | — | |
| SCHEMBL12232802 | 0.84 | MAPT (0.42) | ADAMTS5MMP2 | |
| SCHEMBL12232822 | 0.84 | ADAMTS5 (0.44) | ADAMTS5MMP2ADAM17 | |
| SCHEMBL12508983 | 0.83 | GRIN2D (0.54) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110251212-A1 | PIPERAZINE DERIVATIVES | SHIONOGI & CO., LTD. (JP) | 2011-10-13 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110251212-A1 | PIPERAZINE DERIVATIVES | GRIN2C, NR2C2, GRIN3A | ADAMTS5 4846/4885MMP2 4094/4885ADAM17 3481/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.