Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 15/20 | 0.40 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.36 |
| ▸ | GPR6 | P46095 | 3/20 | 0.33 |
| ▸ | SCD | O00767 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12234558 | 0.92 | GPR119 (0.40) | GPR119KCNH2SCD | |
| SCHEMBL12234591 | 0.91 | GPR119 (0.49) | GPR119KCNH2SCD | |
| SCHEMBL12234536 | 0.89 | GPR119 (0.53) | GPR119KCNH2 | |
| SCHEMBL2539390 | 0.89 | GPR119 (0.43) | GPR119KCNH2GPR6SCD | |
| SCHEMBL12234553 | 0.87 | GPR119 (0.42) | GPR119KCNH2 | |
| SCHEMBL2542106 | 0.83 | GPR119 (0.44) | GPR119KCNH2SCD | |
| SCHEMBL1551053 | 0.82 | GPR119 (0.42) | GPR119KCNH2 | |
| SCHEMBL1550301 | 0.80 | GPR119 (0.56) | GPR119KCNH2 | |
| SCHEMBL2538528 | 0.80 | GPR119 (0.43) | GPR119KCNH2SCD | |
| SCHEMBL2536196 | 0.80 | GPR119 (0.51) | GPR119KCNH2GPR6SCD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20130131074-A1 | PYRIDONE AND PYRIDAZONE ANALOGUES AS GPR119 MODULATORS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2013-05-23 | — | — | US | disclosed |
| US-8372837-B2 | Pyridone and pyridazone analogues as GPR119 modulators | BRISTOL-MYERS SQUIBB COMPANY (US) | 2013-02-12 | — | — | US | disclosed |
| US-20110263548-A1 | PYRIDONE AND PYRIDAZONE ANALOGUES AS GPR119 MODULATORS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2011-10-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130131074-A1 | PYRIDONE AND PYRIDAZONE ANALOGUES AS GPR119 MODULATORS | GPR119, GPR4, GPR3 | GPR119 1/4885KCNH2 929/4885GPR6 7/4885 |
| US-20110263548-A1 | PYRIDONE AND PYRIDAZONE ANALOGUES AS GPR119 MODULATORS | GPR119, GPR4, GPR3 | GPR119 1/4885KCNH2 869/4885GPR6 7/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.