Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KLK7 | P49862 | 7/20 | 0.65 |
| ▸ | KLK5 | Q9Y337 | 4/20 | 0.48 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.45 |
| ▸ | TACR1 | P25103 | 3/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | PREP | P48147 | 2/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | THRB | P10828 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | PARP1 | P09874 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12239673 | 0.94 | KLK7 (0.59) | KLK7KLK5HCRTR2KMT2AMEN1 | |
| SCHEMBL17674479 | 0.89 | KLK7 (0.63) | KLK7KLK5HCRTR2TACR1KMT2A | |
| SCHEMBL21996511 | 0.82 | KLK7 (0.57) | KLK7KLK5HCRTR2TACR1KMT2A | |
| SCHEMBL5754951 | 0.80 | KLK7 (0.59) | KLK7HCRTR2TACR1KMT2AMEN1 | |
| SCHEMBL20444437 | 0.80 | KLK7 (0.57) | KLK7KLK5HCRTR2TACR1KMT2A | |
| SCHEMBL5938277 | 0.79 | KLK7 (0.59) | KLK7KLK5HCRTR2TACR1KMT2A | |
| SCHEMBL13495419 | 0.79 | KLK7 (0.54) | KLK7KLK5HCRTR2TACR1KMT2A | |
| SCHEMBL2983392 | 0.78 | KLK7 (0.53) | KLK7KLK5HCRTR2KMT2AMEN1 | |
| SCHEMBL31034880 | 0.78 | HCRTR2 (0.53) | KLK7HCRTR2TACR1KMT2AMEN1 | |
| SCHEMBL29998466 | 0.77 | KLK7 (0.52) | KLK7KLK5HCRTR2KMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20160317498-A1 | HALOFUGINONE ANALOGS FOR INHIBITION OF TRNA SYNTHETASES AND USES THEREOF | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2016-11-03 | — | — | US | disclosed |
| US-20160317498-A1 | HALOFUGINONE ANALOGS FOR INHIBITION OF TRNA SYNTHETASES AND USES THEREOF | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2016-11-03 | — | — | US | disclosed |
| US-9284297-B2 | Halofuginone analogs for inhibition of tRNA synthetases and uses thereof | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2016-03-15 | — | — | US | disclosed |
| US-20110263532-A1 | HALOFUGINONE ANALOGS FOR INHIBITION OF TRNA SYNTHETASES AND USES THEREOF | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2011-10-27 | — | — | US | disclosed |
| US-20110263532-A1 | HALOFUGINONE ANALOGS FOR INHIBITION OF TRNA SYNTHETASES AND USES THEREOF | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2011-10-27 | — | — | US | disclosed |
| WO-2010019210-A2 | HALOFUGINONE ANALOGS FOR INHIBITION OF TRNA SYNTHETASES AND USES THEREOF | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2010-02-18 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110263532-A1 | HALOFUGINONE ANALOGS FOR INHIBITION OF TRNA SYNTHETASES AND USES THEREOF | FUCA1, GARS1, AARS1 | KLK7 3004/4885KLK5 2391/4885HCRTR2 2669/4885 |
| US-20160317498-A1 | HALOFUGINONE ANALOGS FOR INHIBITION OF TRNA SYNTHETASES AND USES THEREOF | FUCA1, GARS1, AARS1 | KLK7 3004/4885KLK5 2391/4885HCRTR2 2669/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.