Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CREBBP | Q92793 | 2/20 | 0.44 |
| ▸ | BRD4 | O60885 | 1/20 | 0.44 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.36 |
| ▸ | HTR2C | P28335 | 3/20 | 0.34 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.34 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.34 |
| ▸ | HTR2A | P28223 | 1/20 | 0.34 |
| ▸ | HTR2B | P41595 | 1/20 | 0.34 |
| ▸ | CA1 | P00915 | 1/20 | 0.33 |
| ▸ | CA2 | P00918 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | MAOB | P27338 | 3/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18322197 | 1.00 | CREBBP (0.44) | CREBBPBRD4NTRK1TDP1AKR1B1 | |
| SCHEMBL18322195 | 1.00 | CREBBP (0.44) | CREBBPBRD4NTRK1TDP1AKR1B1 | |
| SCHEMBL20297434 | 0.80 | ALDH1A1 (0.38) | CREBBPBRD4HTR2CHTR2AHTR2B | |
| SCHEMBL18325487 | 0.80 | ALDH1A1 (0.38) | CREBBPBRD4HTR2CHTR2AHTR2B | |
| SCHEMBL12264786 | 0.80 | HTR2C (0.44) | NTRK1TDP1HTR2CCHRNB2CHRNA4 | |
| SCHEMBL20255770 | 0.78 | PNMT (0.46) | NTRK1TDP1HTR2CCHRNB2CHRNA4 | |
| SCHEMBL18322005 | 0.77 | OXTR (0.48) | CREBBPBRD4NTRK1HTR2CHTR2A | |
| SCHEMBL18322678 | 0.77 | OXTR (0.48) | CREBBPBRD4NTRK1HTR2CHTR2A | |
| SCHEMBL18322019 | 0.77 | OXTR (0.48) | CREBBPBRD4NTRK1HTR2CHTR2A | |
| SCHEMBL15667383 | 0.77 | TDP1 (0.57) | CREBBPBRD4TDP1AKR1B1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110263569-A1 | RYANODINE CHANNEL BINDERS AND USES THEREOF | PRESIDENT AND FELLOWS OF HARVARD COLLEGE | 2011-10-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110263569-A1 | RYANODINE CHANNEL BINDERS AND USES THEREOF | RYR2, RYR1, CACNA1F | CREBBP 824/4885BRD4 266/4885NTRK1 4006/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.