Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKR1B1 | P15121 | 1/20 | 0.53 |
| ▸ | CXCL8 | P10145 | 3/20 | 0.38 |
| ▸ | CLIC1 | O00299 | 1/20 | 0.38 |
| ▸ | CLCN2 | P51788 | 1/20 | 0.38 |
| ▸ | THRB | P10828 | 2/20 | 0.37 |
| ▸ | PTGS2 | P35354 | 3/20 | 0.36 |
| ▸ | CA2 | P00918 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | GAA | P10253 | 2/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | CASP1 | P29466 | 1/20 | 0.36 |
| ▸ | CASP7 | P55210 | 1/20 | 0.36 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.36 |
| ▸ | THRA | P10827 | 1/20 | 0.35 |
| ▸ | RXRA | P19793 | 1/20 | 0.35 |
| ▸ | RXRB | P28702 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1004496 | 0.81 | CYP1A2 (0.45) | AKR1B1CXCL8CLIC1CLCN2THRB | |
| SCHEMBL28725005 | 0.81 | AKR1B1 (0.57) | AKR1B1CXCL8CLIC1CLCN2PTGS2 | |
| SCHEMBL2239127 | 0.81 | AKR1B1 (0.57) | AKR1B1CXCL8CLIC1CLCN2THRB | |
| SCHEMBL31514224 | 0.81 | SMN1; SMN2 (0.40) | PTGS2ALDH1A1GAAKDM4EMAPT | |
| SCHEMBL12245353 | 0.75 | AKR1B1 (0.44) | AKR1B1CXCL8CLIC1CLCN2THRB | |
| SCHEMBL29933615 | 0.74 | AKR1B1 (0.74) | AKR1B1CXCL8PTGS2GAACYP3A4 | |
| SCHEMBL1003898 | 0.74 | AKR1B1 (0.52) | AKR1B1CXCL8CLIC1CLCN2PTGS2 | |
| SCHEMBL18301686 | 0.74 | AKR1B1 (0.57) | AKR1B1CXCL8CLIC1CLCN2PTGS2 | |
| SCHEMBL17410055 | 0.74 | AKR1B1 (0.74) | AKR1B1CXCL8PTGS2GAACYP3A4 | |
| SCHEMBL4560886 | 0.73 | CYP1A2 (0.56) | AKR1B1PTGS2ALDH1A1GAACYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20180338980-A1 | AROMATIC SULFONAMIDE DERIVATIVES | BAYER PHARMA AKTIENGESELLSCHAFT (DE) | 2018-11-29 | — | — | US | disclosed |
| EP-3307715-A1 | AROMATIC SULFONAMIDE DERIVATIVES | Bayer Pharma Aktiengesellschaft (DE) | 2018-04-18 | — | — | EP | disclosed |
| WO-2016198374-A1 | AROMATIC SULFONAMIDE DERIVATIVES | BAYER PHARMA AKTIENGESELLSCHAFT (DE) | 2016-12-15 | — | — | WO | disclosed |
| US-8901038-B2 | Biphenyl-substituted cyclic ketoenols | BAYER CROPSCIENCE AG (DE) | 2014-12-02 | — | — | US | disclosed |
| US-8901038-B2 | Biphenyl-substituted cyclic ketoenols | BAYER CROPSCIENCE AG (DE) | 2014-12-02 | — | — | US | disclosed |
| US-20110230346-A1 | Biphenyl-Substituted Cyclic Ketoenols | BAYER CROPSCIENCE AG (DE) | 2011-09-22 | — | — | US | disclosed |
| US-20110230346-A1 | Biphenyl-Substituted Cyclic Ketoenols | BAYER CROPSCIENCE AG (DE) | 2011-09-22 | — | — | US | disclosed |
| WO-2011098440-A2 | BIPHENYL SUBSTITUTED CYCLICAL KETO-ENOLS | BAYER CROPSCIENCE AG (DE) | 2011-08-18 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180338980-A1 | AROMATIC SULFONAMIDE DERIVATIVES | ARSA, SULT2A1, TPST2 | AKR1B1 859/4885CXCL8 1933/4885CLIC1 3685/4885 |
| US-20110230346-A1 | Biphenyl-Substituted Cyclic Ketoenols | KCNE1, KDM4E, PIKFYVE | AKR1B1 116/4885CXCL8 4301/4885CLIC1 2840/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.