Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.48 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | HRH2 | P25021 | 1/20 | 0.36 |
| ▸ | HRH1 | P35367 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | PAOX | Q6QHF9 | 1/20 | 0.35 |
| ▸ | DRD2 | P14416 | 1/20 | 0.35 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.35 |
| ▸ | PKM | P14618 | 1/20 | 0.35 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14871082 | 0.88 | PKM (0.45) | ALDH1A1POLBLMNAHTTKMT2A | |
| SCHEMBL18389827 | 0.86 | PAOX (0.48) | ALDH1A1MAPTLMNATSHRL3MBTL1 | |
| SCHEMBL19275359 | 0.84 | ALDH1A1 (0.54) | ALDH1A1LMNADRD2SIGMAR1SMN1; SMN2 | |
| SCHEMBL27976380 | 0.83 | ALDH1A1 (0.54) | ALDH1A1MAPTPOLBLMNAHPGD | |
| SCHEMBL18713113 | 0.80 | OPRL1 (0.48) | ALDH1A1HRH3TP53 | |
| SCHEMBL12228840 | 0.79 | ALDH1A1 (0.36) | ALDH1A1MAPTPOLBHTTKMT2A | |
| SCHEMBL18705050 | 0.79 | DAO (0.39) | ALDH1A1MAPTPOLBSIGMAR1HRH3 | |
| SCHEMBL20641807 | 0.78 | ALDH1A1 (0.38) | ALDH1A1MAPTPOLBLMNAHPGD | |
| SCHEMBL2910116 | 0.78 | GLA (0.58) | ALDH1A1MAPTLMNATSHRKMT2A | |
| SCHEMBL14839105 | 0.78 | SIGMAR1 (0.41) | ALDH1A1MAPTPOLBHRH2HRH1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110257100-A1 | Inhibitors of Protein Tyrosine Kinase Activity | METHYLGENE INC. (CA) | 2011-10-20 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110257100-A1 | Inhibitors of Protein Tyrosine Kinase Activity | ERBB2, ABL1, FLT1 | ALDH1A1 4061/4885MAPT 997/4885POLB 2199/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.