Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DAO | P14920 | 1/20 | 0.51 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.46 |
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.45 |
| ▸ | HRH3 | Q9Y5N1 | 7/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.41 |
| ▸ | MBTD1 | Q05BQ5 | 1/20 | 0.41 |
| ▸ | L3MBTL3 | Q96JM7 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | HTR1D | P28221 | 1/20 | 0.38 |
| ▸ | HTR1B | P28222 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 2/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL260284 | 0.80 | KCNH2 (0.44) | HRH3L3MBTL1HTR1DHTR1B | |
| SCHEMBL260550 | 0.74 | SLC6A3 (0.44) | SLC6A3SIGMAR1HRH3L3MBTL1MBTD1 | |
| SCHEMBL261027 | 0.73 | SLC6A3 (0.43) | SLC6A3SIGMAR1HRH3L3MBTL1MBTD1 | |
| SCHEMBL6899153 | 0.73 | DAO (0.60) | DAOL3MBTL1TDP1RAB9AGAA | |
| SCHEMBL1225699 | 0.73 | DAO (0.60) | DAOSLC6A3L3MBTL1TDP1CYP1A2 | |
| SCHEMBL1149656 | 0.71 | DAO (0.73) | DAORAB9AGAA | |
| SCHEMBL7258022 | 0.70 | DAO (0.57) | DAOSIGMAR1HRH3TDP1RAB9A | |
| SCHEMBL7772142 | 0.70 | SLC6A3 (0.61) | SLC6A3SIGMAR1HRH3L3MBTL1MBTD1 | |
| SCHEMBL1149201 | 0.70 | DAO (0.49) | DAOHRH3TDP1RAB9AGAA | |
| SCHEMBL7031548 | 0.69 | HRH3 (0.62) | SLC6A3SIGMAR1HRH3L3MBTL1MBTD1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2281822-B1 | New dihydroindolone derivatives, method of preparing same and pharmaceutical compositions containing them | SERVIER LAB (FR) | 2013-01-16 | — | — | EP | disclosed |
| EP-2281822-A1 | New dihydroindolone derivatives, method of preparing same and pharmaceutical compositions containing them | Les Laboratoires Servier (FR) | 2011-02-09 | — | — | EP | disclosed |