SCHEMBL12256708

SCHEMBL12256708

O=C(O)c1ccc2c(c1)C(=O)C1C=CC=CC1S2

nearest known ligand 0.40

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
PTPRC P08575 2/20 0.40
POLB P06746 5/20 0.39
SMN1; SMN2 Q16637 2/20 0.39
KMT2A Q03164 2/20 0.38
TTR P02766 3/20 0.37
HTT P42858 1/20 0.35
TDP1 Q9NUW8 3/20 0.34
L3MBTL1 Q9Y468 3/20 0.34
PABPC1 P11940 1/20 0.34
HSD17B10 Q99714 1/20 0.34
HPGD P15428 2/20 0.34
CSNK2A2 P19784 1/20 0.33
CSNK2B P67870 1/20 0.33
CSNK2A1 P68400 1/20 0.33
CSNK2A3 Q8NEV1 1/20 0.33
LMNA P02545 1/20 0.33
TDP2 O95551 1/20 0.33
MAPT P10636 3/20 0.32
KDM4E B2RXH2 3/20 0.32
MEN1 O00255 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL11937040 0.74 POLB (0.57) PTPRCPOLBSMN1; SMN2KMT2ATTR
SCHEMBL4096667 0.73 ALOX5 (0.37) PTPRCPOLBSMN1; SMN2KMT2AHTT
SCHEMBL31686219 0.63 PTPRC (0.84) PTPRCPOLBKMT2ATTRTDP1
SCHEMBL13931149 0.61 HTT (0.55) PTPRCPOLBSMN1; SMN2KMT2ATTR
SCHEMBL69805 0.60 PTPRC (0.72) PTPRCPOLBKMT2ATTRTDP1
SCHEMBL68062 0.60 PTPRC (0.72) PTPRCPOLBKMT2ATTRTDP1
SCHEMBL11937039 0.60 TTR (0.52) PTPRCPOLBSMN1; SMN2KMT2ATTR
SCHEMBL11983054 0.60 TTR (0.47) PTPRCPOLBSMN1; SMN2KMT2ATTR
SCHEMBL12106079 0.59 TSHR (0.50) POLBSMN1; SMN2HTTTDP1L3MBTL1
SCHEMBL68522 0.59 TSHR (0.50) POLBSMN1; SMN2HTTTDP1L3MBTL1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2199273-B1 Polymerizable photoinitiators and radiation curable compositions AGFA NV (BE) 2018-02-21 EP disclosed
US-8492452-B2 Polymerizable photoinitiators and radiation curable compositions AGFA GRAPHICS NV (BE) 2013-07-23 US disclosed
US-8492452-B2 Polymerizable photoinitiators and radiation curable compositions AGFA GRAPHICS NV (BE) 2013-07-23 US disclosed
US-20110224324-A1 POLYMERIZABLE PHOTOINITIATORS AND RADIATION CURABLE COMPOSITIONS AGFA GRAPHICS NV (BE) 2011-09-15 US disclosed
US-20110224324-A1 POLYMERIZABLE PHOTOINITIATORS AND RADIATION CURABLE COMPOSITIONS AGFA GRAPHICS NV (BE) 2011-09-15 US disclosed
EP-2199273-A1 Polymerizable photoinitiators and radiation curable compositions AGFA Graphics NV (BE) 2010-06-23 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20110224324-A1 POLYMERIZABLE PHOTOINITIATORS AND RADIATION CURABLE COMPOSITIONS WEE1, ZYX, MTR PTPRC 3742/4885POLB 1031/4885SMN1; SMN2 4359/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.