Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLA1 | P09884 | 1/20 | 0.39 |
| ▸ | APP | P05067 | 1/20 | 0.38 |
| ▸ | CYP46A1 | Q9Y6A2 | 2/20 | 0.37 |
| ▸ | NR1H3 | Q13133 | 2/20 | 0.37 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.36 |
| ▸ | EPHA2 | P29317 | 5/20 | 0.36 |
| ▸ | USP2 | O75604 | 2/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.35 |
| ▸ | OSBP | P22059 | 1/20 | 0.35 |
| ▸ | RORC | P51449 | 1/20 | 0.35 |
| ▸ | OSBP2 | Q969R2 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | NPC1L1 | Q9UHC9 | 1/20 | 0.34 |
| ▸ | GBA1 | P04062 | 2/20 | 0.33 |
| ▸ | UGCG | Q16739 | 2/20 | 0.33 |
| ▸ | GBA2 | Q9HCG7 | 2/20 | 0.33 |
| ▸ | EPHB6 | O15197 | 1/20 | 0.33 |
| ▸ | EPHA1 | P21709 | 1/20 | 0.33 |
| ▸ | EPHA3 | P29320 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13610651 | 0.93 | POLA1 (0.39) | POLA1APPCYP46A1NR1H3PLA2G2A | |
| SCHEMBL13032470 | 0.93 | POLA1 (0.39) | POLA1APPCYP46A1NR1H3PLA2G2A | |
| SCHEMBL13610648 | 0.84 | POLA1 (0.36) | POLA1APPCYP46A1NR1H3PLA2G2A | |
| SCHEMBL12259014 | 0.84 | POLA1 (0.36) | POLA1APPCYP46A1NR1H3PLA2G2A | |
| SCHEMBL11992553 | 0.77 | PLA2G2A (0.47) | POLA1APPCYP46A1NR1H3PLA2G2A | |
| SCHEMBL13610652 | 0.77 | EPHA2 (0.40) | EPHA2LMNA | |
| SCHEMBL12258949 | 0.76 | POLA1 (0.49) | POLA1CYP46A1NR1H3PLA2G2AEPHA2 | |
| SCHEMBL11992542 | 0.76 | PLA2G2A (0.46) | POLA1APPCYP46A1NR1H3PLA2G2A | |
| SCHEMBL24141990 | 0.76 | POLA1 (0.45) | POLA1APPCYP46A1NR1H3PLA2G2A | |
| SCHEMBL4546174 | 0.76 | POLA1 (0.45) | POLA1APPCYP46A1NR1H3PLA2G2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8017763-B2 | Chemically modified oligonucleotides | ALNYLAM PHARMACEUTICALS, INC. (US) | 2011-09-13 | — | — | US | disclosed |
| US-20100069471-A1 | CHEMICALLY MODIFIED OLIGONUCLEOTIDES | ALNYLAM PHARMACEUTICALS, INC. (US) | 2010-03-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100069471-A1 | CHEMICALLY MODIFIED OLIGONUCLEOTIDES | NSUN2, RNGTT, DCLRE1B | POLA1 224/4885APP 4692/4885CYP46A1 3991/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.