Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CALCRL | Q16602 | 6/20 | 0.40 |
| ▸ | RAMP1 | O60894 | 2/20 | 0.39 |
| ▸ | CALCA | P06881 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | SLC6A9 | P48067 | 1/20 | 0.34 |
| ▸ | AR | P10275 | 2/20 | 0.33 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.33 |
| ▸ | MDM2 | Q00987 | 2/20 | 0.32 |
| ▸ | TP53 | P04637 | 1/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.31 |
| ▸ | HTT | P42858 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12263085 | 0.99 | CALCRL (0.41) | CALCRLRAMP1CALCAALDH1A1SLC6A9 | |
| SCHEMBL15354511 | 0.85 | CALCRL (0.41) | CALCRLRAMP1CALCAALDH1A1SLC6A9 | |
| SCHEMBL15354514 | 0.84 | CALCRL (0.41) | CALCRLRAMP1CALCAALDH1A1AR | |
| SCHEMBL1273297 | 0.84 | CALCRL (0.45) | CALCRLRAMP1CALCARIPK1MDM2 | |
| SCHEMBL1226173 | 0.84 | CALCRL (0.45) | CALCRLRAMP1CALCARIPK1MDM2 | |
| SCHEMBL1273885 | 0.84 | CALCRL (0.45) | CALCRLRAMP1CALCARIPK1MDM2 | |
| SCHEMBL12263094 | 0.77 | RIPK1 (0.40) | CALCRLRIPK1MDM2TP53 | |
| SCHEMBL3590594 | 0.76 | CALCRL (0.54) | CALCRLRAMP1CALCARIPK1L3MBTL1 | |
| SCHEMBL3590576 | 0.76 | CALCRL (0.54) | CALCRLRAMP1CALCARIPK1L3MBTL1 | |
| SCHEMBL3592002 | 0.76 | CALCRL (0.54) | CALCRLRAMP1CALCARIPK1L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8569291-B2 | Bicyclic dihydroimidazolone CGRP receptor antagonists | MERCK SHARP & DOHME CORP. (US) | 2013-10-29 | — | — | US | disclosed |
| US-20110224230-A1 | BICYCLIC DIHYDROIMIDAZOLONE CGRP RECEPTOR ANTAGONISTS | MERCK SHARP & DOHME LLC | 2011-09-15 | — | — | US | disclosed |
| US-20110224230-A1 | BICYCLIC DIHYDROIMIDAZOLONE CGRP RECEPTOR ANTAGONISTS | MERCK SHARP & DOHME LLC | 2011-09-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110224230-A1 | BICYCLIC DIHYDROIMIDAZOLONE CGRP RECEPTOR ANTAGONISTS | BDKRB1, BDKRB2, CCKBR | CALCRL 4/4885RAMP1 110/4885CALCA 9/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.