SCHEMBL1226409

SCHEMBL1226409

Fc1ccc(C2CCc3c(NCCC4CC4)nc(Cl)nc32)cc1

nearest known ligand 0.33

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP3A4 P08684 2/20 0.33
PSEN1 P49768 2/20 0.33
PSEN2 P49810 2/20 0.33
APH1B Q8WW43 2/20 0.33
NCSTN Q92542 2/20 0.33
APH1A Q96BI3 2/20 0.33
PSENEN Q9NZ42 2/20 0.33
CYP2C8 P10632 1/20 0.33
CYP2D6 P10635 1/20 0.33
CYP2C9 P11712 1/20 0.33
UGT1A1 P22309 1/20 0.33
CYP2C19 P33261 1/20 0.33
KCNH2 Q12809 1/20 0.33
SLCO1B1 Q9Y6L6 1/20 0.33
OPRL1 P41146 7/20 0.32
ACHE P22303 4/20 0.31
BCHE P06276 1/20 0.31
AXL P30530 1/20 0.31
FLT3 P36888 1/20 0.31
TYRO3 Q06418 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1226408 1.00 CYP3A4 (0.33) CYP3A4PSEN1PSEN2APH1BNCSTN
SCHEMBL1226814 1.00 CYP3A4 (0.33) CYP3A4PSEN1PSEN2APH1BNCSTN
SCHEMBL12318431 0.88 HTR2B (0.36) CYP3A4PSEN1PSEN2APH1BNCSTN
SCHEMBL10279390 0.87 STK17B (0.34) CYP3A4PSEN1PSEN2APH1BNCSTN
SCHEMBL10279539 0.86 CYP3A4 (0.37) CYP3A4PSEN1PSEN2APH1BNCSTN
SCHEMBL512570 0.85 KCNH3 (0.35) CYP3A4PSEN1PSEN2APH1BNCSTN
SCHEMBL513570 0.82 KDM4E (0.40) CYP3A4PSEN1PSEN2APH1BNCSTN
SCHEMBL360552 0.82 ALDH1A1 (0.42) CYP3A4PSEN1PSEN2APH1BNCSTN
SCHEMBL511864 0.81 CYP3A4 (0.46) CYP3A4PSEN1PSEN2APH1BNCSTN
SCHEMBL1226458 0.80 ACHE (0.34) OPRL1ACHEBCHEAXLFLT3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2668168-A1 COMPOUNDS FOR THE REDUCTION OF ß-AMYLOID PRODUCTION Bristol-Myers Squibb Company (US) 2013-12-04 EP disclosed
WO-2012103297-A1 COMPOUNDS FOR THE REDUCTION OF β-AMYLOID PRODUCTION BRISTOL-MYERS SQUIBB COMPANY (US) 2012-08-02 WO disclosed
EP-2459197-A1 COMPOUNDS FOR THE REDUCTION OF -AMYLOID PRODUCTION Bristol-Myers Squibb Company (US) 2012-06-06 EP disclosed
WO-2011014535-A1 COMPOUNDS FOR THE REDUCTION OF β-AMYLOID PRODUCTION BRISTOL-MYERS SQUIBB COMPANY (US) 2011-02-03 WO disclosed