Sugi Predict

Sugi Predict / Compounds / SCHEMBL12269366

SCHEMBL12269366

SCHEMBL12269366

CCOC(=O)C12CCC(C(=O)Cl)(CC1)CC2

nearest known ligand 0.37

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ MEN1 O00255 1/20 0.37
▸ KMT2A Q03164 1/20 0.37
▸ ALDH1A1 P00352 2/20 0.37
▸ POLB P06746 1/20 0.37
▸ OPRM1 P35372 6/20 0.36
▸ LMNA P02545 2/20 0.36
▸ SMN1; SMN2 Q16637 1/20 0.36
▸ HSD17B10 Q99714 1/20 0.36
▸ ATM Q13315 1/20 0.35
▸ OPRD1 P41143 3/20 0.35
▸ OPRK1 P41145 3/20 0.35
▸ SLC22A1 O15245 1/20 0.35
▸ SLC6A4 P31645 1/20 0.35
▸ ADRA1A P35348 1/20 0.35
▸ KCNH2 Q12809 1/20 0.35
▸ ALOX15 P16050 1/20 0.34
▸ MGAM O43451 1/20 0.34
▸ GAA P10253 1/20 0.34
▸ SI P14410 1/20 0.34
▸ MGAM2 Q2M2H8 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL17893420 0.89 ALDH1A1 (0.46) MEN1KMT2AALDH1A1POLBOPRM1
SCHEMBL20851049 0.83 POLB (0.41) MEN1KMT2AALDH1A1POLBOPRM1
SCHEMBL19357061 0.83 POLB (0.41) MEN1KMT2AALDH1A1POLBOPRM1
SCHEMBL20851071 0.83 POLB (0.41) MEN1KMT2AALDH1A1POLBOPRM1
SCHEMBL1306329 0.81 ALOX15 (0.41) MEN1KMT2AALDH1A1POLBOPRM1
SCHEMBL1566652 0.81 OPRM1 (0.40) MEN1KMT2AALDH1A1POLBOPRM1
SCHEMBL15583281 0.81 OPRM1 (0.40) MEN1KMT2AALDH1A1POLBOPRM1
SCHEMBL22640209 0.80 POLB (0.44) MEN1KMT2AALDH1A1POLBOPRM1
SCHEMBL12302983 0.79 ALDH1A1 (0.37) MEN1KMT2AALDH1A1POLBOPRM1
Bromide SCHEMBL1494095 0.79 ALOX15 (0.39) MEN1KMT2AALDH1A1POLBOPRM1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20170049904-A1 POLYALKYLENE POLYMER COMPOUNDS AND USES THEREOF BIOGEN MA INC. (US) 2017-02-23 — — US disclosed
US-20150246097-A9 Polyalkylene Polymer Compounds and Uses Thereof BIOGEN IDEC MA INC. (US) 2015-09-03 — — US disclosed
US-20150132259-A1 Polyalkylene Polymer Compounds and Uses Thereof BIOGEN IDEC MA INC. (US) 2015-05-14 — — US disclosed
US-8017733-B2 Covalent attachment of hydrophilic polymers, such as polyalkylene glycol polymers, also known as polyalkylene oxides, to biologically-active molecules BIOGEN IDEC MA INC. (US) 2011-09-13 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20150246097-A9 Polyalkylene Polymer Compounds and Uses Thereof HAVCR2, TLR3, CCR8 MEN1 4797/4885KMT2A 3367/4885ALDH1A1 1052/4885
US-20170049904-A1 POLYALKYLENE POLYMER COMPOUNDS AND USES THEREOF HAVCR2, TLR3, CCR8 MEN1 4797/4885KMT2A 3367/4885ALDH1A1 1052/4885
US-20150132259-A1 Polyalkylene Polymer Compounds and Uses Thereof HAVCR2, TLR3, CCR8 MEN1 4797/4885KMT2A 3367/4885ALDH1A1 1052/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.