Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | RECQL | P46063 | 1/20 | 0.40 |
| ▸ | HSP90AB1 | P08238 | 2/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.34 |
| ▸ | MAOB | P27338 | 1/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | KDM6B | O15054 | 1/20 | 0.34 |
| ▸ | KDM5C | P41229 | 1/20 | 0.34 |
| ▸ | KDM2A | Q9Y2K7 | 1/20 | 0.34 |
| ▸ | KDM3A | Q9Y4C1 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12275953 | 0.81 | ALDH1A1 (0.35) | GAAALDH1A1CYP1A2CYP2C9HSP90AB1 | |
| SCHEMBL1461804 | 0.78 | HSP90AB1 (0.47) | GAAALDH1A1CYP1A2CYP2C9RECQL | |
| SCHEMBL12275365 | 0.75 | HSP90AB1 (0.45) | GAAALDH1A1CYP1A2CYP2C9RECQL | |
| SCHEMBL1461801 | 0.73 | GAA (0.38) | GAAALDH1A1CYP1A2CYP2C9RECQL | |
| SCHEMBL4917285 | 0.71 | GAA (0.54) | GAAALDH1A1CYP1A2CYP2C9RECQL | |
| SCHEMBL12451342 | 0.70 | CA1 (0.46) | GAAALDH1A1RECQLHSP90AB1POLB | |
| SCHEMBL1461856 | 0.70 | GAA (0.40) | GAAALDH1A1CYP1A2CYP2C9RECQL | |
| SCHEMBL18839649 | 0.70 | HSP90AB1 (0.49) | GAAALDH1A1RECQLHSP90AB1 | |
| SCHEMBL20518699 | 0.69 | GAA (0.40) | GAAALDH1A1CYP1A2CYP2C9RECQL | |
| SCHEMBL18839831 | 0.67 | GAA (0.53) | GAAALDH1A1CYP1A2CYP2C9RECQL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120238488-A1 | COMPOUNDS AND METHODS FOR TREATING NEOPLASIA | PHARMACELLION LTD. (GB) | 2012-09-20 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120238488-A1 | COMPOUNDS AND METHODS FOR TREATING NEOPLASIA | VHL, KRAS, TP53 | GAA 1132/4885ALDH1A1 313/4885CYP1A2 1028/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.