Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 1/20 | 0.36 |
| ▸ | HTR2C | P28335 | 1/20 | 0.36 |
| ▸ | HTR2B | P41595 | 1/20 | 0.36 |
| ▸ | CYP1A1 | P04798 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CYP1B1 | Q16678 | 1/20 | 0.35 |
| ▸ | MAPK14 | Q16539 | 4/20 | 0.35 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.35 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.35 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.35 |
| ▸ | GCGR | P47871 | 3/20 | 0.35 |
| ▸ | MAPK13 | O15264 | 2/20 | 0.35 |
| ▸ | MAPK12 | P53778 | 2/20 | 0.35 |
| ▸ | MAPK11 | Q15759 | 2/20 | 0.35 |
| ▸ | PTGS2 | P35354 | 7/20 | 0.34 |
| ▸ | PTGS1 | P23219 | 3/20 | 0.34 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | PKM | P14618 | 1/20 | 0.33 |
| ▸ | MYC | P01106 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6909946 | 0.77 | HTR2A (0.39) | HTR2AHTR2CHTR2BCYP1A1CYP1A2 | |
| SCHEMBL16692648 | 0.72 | ADORA1 (0.47) | CYP1A1CYP1A2CYP1B1PTGS2ALDH1A1 | |
| SCHEMBL23791840 | 0.62 | KDM5B (0.40) | KDM5BALDH1A1MYCWDR5PTGDR2 | |
| SCHEMBL3826066 | 0.62 | ALDH1A1 (0.39) | PTGS2ALDH1A1MYCWDR5PTGDR2 | |
| SCHEMBL23782515 | 0.61 | MYC (0.50) | CYP1A2PTGS2ALDH1A1MYCWDR5 | |
| SCHEMBL10589844 | 0.61 | ADORA2A (0.44) | HTR2AHTR2CHTR2BMAPK14MAPK9 | |
| SCHEMBL17051053 | 0.61 | ADAMTS5 (0.46) | CYP1A1CYP1A2CYP1B1ALDH1A1PTGDR2 | |
| SCHEMBL12661406 | 0.61 | NTRK1 (0.49) | CYP1A1CYP1A2CYP1B1PTGS2PTGS1 | |
| SCHEMBL14275905 | 0.61 | CYP1A1 (0.49) | CYP1A1CYP1A2CYP1B1PTGS2ALDH1A1 | |
| SCHEMBL3825168 | 0.60 | ALDH1A1 (0.64) | CYP1A2PTGS2ALDH1A1MYCWDR5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20130231335-A1 | INHIBITORS OF POLO-LIKE KINASE | ELAN PHARMACEUTICALS, INC. (US) | 2013-09-05 | — | — | US | disclosed |
| US-8445503-B2 | Inhibitors of polo-like kinase | ELAN PHARMACEUTICALS, INC. (US) | 2013-05-21 | — | — | US | disclosed |
| US-20110212942-A1 | INHIBITORS OF POLO-LIKE KINASE | ELAN PHARMACEUTICALS, INC. | 2011-09-01 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110212942-A1 | INHIBITORS OF POLO-LIKE KINASE | PLK1, POLK, POLR2E | HTR2A 4444/4885HTR2C 4521/4885HTR2B 4356/4885 |
| US-20130231335-A1 | INHIBITORS OF POLO-LIKE KINASE | POLK, PLK1, POLR2E | HTR2A 4454/4885HTR2C 4540/4885HTR2B 4381/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.