Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TGFBR1 | P36897 | 17/20 | 0.55 |
| ▸ | MAPK14 | Q16539 | 3/20 | 0.50 |
| ▸ | TGFBR2 | P37173 | 1/20 | 0.48 |
| ▸ | ABL2 | P42684 | 1/20 | 0.48 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.48 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.48 |
| ▸ | MAP3K20 | Q9NYL2 | 1/20 | 0.48 |
| ▸ | ACVR1B | P36896 | 1/20 | 0.43 |
| ▸ | METAP2 | P50579 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | CCR1 | P32246 | 1/20 | 0.42 |
| ▸ | CCR5 | P51681 | 1/20 | 0.42 |
| ▸ | CCR8 | P51685 | 1/20 | 0.42 |
| ▸ | METAP1 | P53582 | 1/20 | 0.42 |
| ▸ | BLM | P54132 | 1/20 | 0.42 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.42 |
| ▸ | DOHH | Q9BU89 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14960651 | 0.77 | TGFBR1 (0.60) | TGFBR1MAPK14TGFBR2ABL2CSNK1A1 | |
| SCHEMBL10413171 | 0.75 | TGFBR1 (0.77) | TGFBR1MAPK14TGFBR2ABL2CSNK1A1 | |
| SCHEMBL12277788 | 0.75 | RPS6KA3 (0.47) | TGFBR1MAPK14METAP2KDM4ELMNA | |
| SCHEMBL26453218 | 0.74 | TGFBR1 (0.60) | TGFBR1MAPK14TGFBR2ABL2CSNK1A1 | |
| SCHEMBL30919457 | 0.74 | TGFBR1 (0.60) | TGFBR1MAPK14TGFBR2ABL2CSNK1A1 | |
| SCHEMBL29118400 | 0.71 | KDM4E (0.52) | KDM4ELMNACYP1A2POLBCCR1 | |
| SCHEMBL12277249 | 0.70 | TSHR (0.35) | TGFBR1METAP2KDM4ECYP1A2METAP1 | |
| SCHEMBL8227726 | 0.69 | KDM4E (0.50) | KDM4ELMNACYP1A2POLBCCR1 | |
| SCHEMBL29986460 | 0.68 | KDM4E (0.48) | KDM4ELMNACYP1A2POLBCCR1 | |
| SCHEMBL31358283 | 0.68 | KDM4E (0.48) | KDM4ELMNACYP1A2POLBCCR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11858912-B2 | Heterocyclic compounds | HOFFMANN-LA ROCHE INC. (US) | 2024-01-02 | — | — | US | disclosed |
| US-20230133845-A1 | NOVEL HETEROCYCLIC COMPOUNDS | HOFFMANN-LA ROCHE INC. (US) | 2023-05-04 | — | — | US | disclosed |
| US-20230133845-A1 | NOVEL HETEROCYCLIC COMPOUNDS | HOFFMANN-LA ROCHE INC. (US) | 2023-05-04 | — | — | US | disclosed |
| US-20150126502-A1 | INHIBITORS OF POLO-LIKE KINASE | ELAN PHARM INC (US) | 2015-05-07 | — | — | US | disclosed |
| US-20130231335-A1 | INHIBITORS OF POLO-LIKE KINASE | ELAN PHARMACEUTICALS, INC. (US) | 2013-09-05 | — | — | US | disclosed |
| US-8445503-B2 | Inhibitors of polo-like kinase | ELAN PHARMACEUTICALS, INC. (US) | 2013-05-21 | — | — | US | disclosed |
| US-20110212942-A1 | INHIBITORS OF POLO-LIKE KINASE | ELAN PHARMACEUTICALS, INC. | 2011-09-01 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11858912-B2 | Heterocyclic compounds | F12, C1R, MRPL21 | TGFBR1 1666/4885MAPK14 3148/4885TGFBR2 3057/4885 |
| US-20110212942-A1 | INHIBITORS OF POLO-LIKE KINASE | PLK1, POLK, POLR2E | TGFBR1 2291/4885MAPK14 754/4885TGFBR2 2993/4885 |
| US-20130231335-A1 | INHIBITORS OF POLO-LIKE KINASE | POLK, PLK1, POLR2E | TGFBR1 2340/4885MAPK14 753/4885TGFBR2 3077/4885 |
| US-20150126502-A1 | INHIBITORS OF POLO-LIKE KINASE | POLK, PLK1, POLR2E | TGFBR1 2340/4885MAPK14 753/4885TGFBR2 3077/4885 |
| US-20230133845-A1 | NOVEL HETEROCYCLIC COMPOUNDS | F12, PM20D2, XDH | TGFBR1 1684/4885MAPK14 2908/4885TGFBR2 3244/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.