Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | HTR6 | P50406 | 1/20 | 0.49 |
| ▸ | ESR1 | P03372 | 4/20 | 0.48 |
| ▸ | ESRRG | P62508 | 3/20 | 0.48 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.48 |
| ▸ | ESR2 | Q92731 | 2/20 | 0.48 |
| ▸ | RAB9A | P51151 | 2/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | FFAR1 | O14842 | 2/20 | 0.43 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.42 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.40 |
| ▸ | PLA2G4B | P0C869 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | PPARG | P37231 | 1/20 | 0.39 |
| ▸ | PPARD | Q03181 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12134462 | 0.90 | PTGS2 (0.51) | HTR6ESR1ESRRGCYP19A1ESR2 | |
| SCHEMBL12284881 | 0.85 | ESR1 (0.65) | LMNAHTR6ESR1ESRRGCYP19A1 | |
| SCHEMBL9860167 | 0.80 | ESR1 (0.66) | LMNAHTR6ESR1ESRRGCYP19A1 | |
| SCHEMBL9860174 | 0.80 | ESR1 (0.66) | LMNAHTR6ESR1ESRRGCYP19A1 | |
| SCHEMBL9860177 | 0.80 | ESR1 (0.66) | LMNAHTR6ESR1ESRRGCYP19A1 | |
| SCHEMBL17506016 | 0.79 | LMNA (0.64) | LMNAHTR6ESR1ESRRGCYP19A1 | |
| SCHEMBL17506017 | 0.79 | LMNA (0.64) | LMNAHTR6ESR1ESRRGCYP19A1 | |
| SCHEMBL17506015 | 0.79 | LMNA (0.64) | LMNAHTR6ESR1ESRRGCYP19A1 | |
| SCHEMBL12282316 | 0.79 | ESR1 (0.65) | LMNAHTR6ESR1ESRRGCYP19A1 | |
| SCHEMBL13971003 | 0.76 | HTR6 (0.69) | LMNAHTR6ESR1ESRRGCYP19A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011129837-A1 | USE OF A 4-HYDROXYTOREMIFENE PRODRUG FOR TREATMENT OF BREAST CANCER | OLEMA PHARMACEUTICALS, INC. (US) | 2011-10-20 | — | — | WO | disclosed |