Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CSNK2A2 | P19784 | 12/20 | 0.53 |
| ▸ | CSNK2A1 | P68400 | 12/20 | 0.53 |
| ▸ | RIPK1 | Q13546 | 5/20 | 0.41 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.40 |
| ▸ | ACVRL1 | P37023 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14654945 | 0.86 | CSNK2A2 (0.53) | CSNK2A2CSNK2A1RIPK1PIK3CDACVRL1 | |
| SCHEMBL14654922 | 0.82 | CSNK2A2 (0.53) | CSNK2A2CSNK2A1RIPK1PIK3CDACVRL1 | |
| SCHEMBL12283230 | 0.82 | CSNK2A2 (0.67) | CSNK2A2CSNK2A1RIPK1 | |
| SCHEMBL2558402 | 0.81 | CSNK2A2 (0.80) | CSNK2A2CSNK2A1RIPK1PIK3CD | |
| SCHEMBL2546150 | 0.77 | CSNK2A2 (0.81) | CSNK2A2CSNK2A1RIPK1PIK3CD | |
| SCHEMBL12283438 | 0.76 | NTRK1 (0.38) | CSNK2A2CSNK2A1PIK3CDACVRL1 | |
| SCHEMBL12284245 | 0.74 | CSNK2A2 (0.68) | CSNK2A2CSNK2A1ACVRL1 | |
| SCHEMBL14634923 | 0.72 | CSNK2A2 (0.80) | CSNK2A2CSNK2A1 | |
| SCHEMBL14634927 | 0.70 | CSNK2A2 (0.83) | CSNK2A2CSNK2A1 | |
| SCHEMBL14635504 | 0.69 | CSNK2A2 (1.00) | CSNK2A2CSNK2A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011123493-A1 | SUBSTITUTED PYRROLOTRIAZINES AS PROTEIN KINASE INHIBITORS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2011-10-06 | — | — | WO | disclosed |