SCHEMBL12284875

SCHEMBL12284875

NC(=O)CCC(=O)ON1C(=O)CCC1=O

nearest known ligand 0.35

Predicted protein targets (top 7)

geneUniProtsupporting neighboursconfidence
TSHR P16473 1/20 0.35
PSMB8 P28062 2/20 0.34
PSMB5 P28074 1/20 0.34
MGLL Q99685 1/20 0.31
L3MBTL1 Q9Y468 1/20 0.31
APEX1 P27695 1/20 0.30
BLM P54132 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL14141320 0.91 SMN1; SMN2 (0.36) TSHRPSMB8PSMB5MGLLL3MBTL1
SCHEMBL12185672 0.91 TSHR (0.34) TSHRPSMB8PSMB5MGLL
SCHEMBL43576 0.90 PSMB8 (0.35) TSHRPSMB8PSMB5MGLL
SCHEMBL21846020 0.89 SMN1; SMN2 (0.38) TSHRPSMB8PSMB5L3MBTL1
SCHEMBL21846055 0.89 SMN1; SMN2 (0.38) TSHRPSMB8PSMB5L3MBTL1
SCHEMBL31522720 0.88 PSMB8 (0.34) PSMB8PSMB5MGLL
SCHEMBL14644916 0.84 PSMB8 (0.33) TSHRPSMB8PSMB5MGLL
SCHEMBL2263421 0.84 MGLL (0.35) PSMB8PSMB5MGLL
Ethylene Glycol SCHEMBL999673 0.84 PSMB8 (0.36) PSMB8PSMB5MGLL
SCHEMBL14769218 0.82 TSHR (0.36) TSHRPSMB8PSMB5MGLLAPEX1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 20 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4299761-B1 SURFACE-FUNCTIONALIZED OPTICAL ELEMENT BETASENSE GMBH (DE) 2026-05-27 EP disclosed
US-20260002946-A1 SURFACE-FUNCTIONALIZED OPTICAL ELEMENT BETASENSE GMBH (DE) 2026-01-01 US disclosed
US-20250052675-A1 Attenuated Total Reflectance-Based Biosensor for Conformation and Secondary Structure Analysis BETASENSE GMBH (DE) 2025-02-13 US disclosed
EP-3542164-B1 METHOD FOR THE PRESELECTION OF DRUGS FOR PROTEIN MISFOLDING DISEASES BETASENSE GMBH (DE) 2025-01-15 EP disclosed
EP-3631446-B1 BIOSENSOR FOR CONFORMATION AND SECONDARY STRUCTURE ANALYSIS BETASENSE GMBH (DE) 2024-04-17 EP disclosed
WO-2024003214-A2 SURFACE-FUNCTIONALIZED OPTICAL ELEMENT BETASENSE GMBH (DE) 2024-01-04 WO disclosed
EP-4299761-A1 SURFACE-FUNCTIONALIZED OPTICAL ELEMENT betaSENSE GmbH (DE) 2024-01-03 EP disclosed
WO-2023176809-A1 METHOD FOR PRODUCING POLYETHYLENE GLYCOL DERIVATIVE 日油株式会社 2023-09-21 WO disclosed
US-11592451-B2 Method for the preselection of drugs for protein misfolding diseases BETASENSE GMBH (DE) 2023-02-28 US disclosed
WO-2022118277-A1 CARBONIC ANHYDRASE INHIBITORS SYNTHESIZED ON INTERCONNECTING LINKER CHAINS VILNIUS UNIVERSITY (LT) 2022-06-09 WO disclosed
US-11237176-B2 Infrared assay detecting secondary structure profiles of alpha-synuclein PROTHENA BIOSCIENCES LIMITED (IE) 2022-02-01 US disclosed
EP-3943942-A1 BIOSENSOR FOR CONFORMATION AND SECONDARY STRUCTURE ANALYSIS betaSENSE GmbH (DE) 2022-01-26 EP disclosed
WO-2019192454-A9 NOVEL SMALL MOLECULE IMMUNE AGONISTS AND IMMUNE TARGETING COMPOUNDS AND APPLICATION THEREOF 深圳大学 2020-01-16 WO disclosed
WO-2019192454-A1 NOVEL SMALL MOLECULE IMMUNE AGONISTS AND IMMUNE TARGETING COMPOUNDS AND APPLICATION THEREOF 深圳大学 2019-10-10 WO disclosed
US-20160120994-A1 BLOOD COAGULATION PROTEIN CONJUGATES BAXALTA INC (US) 2016-05-05 US disclosed
WO-2011130577-A1 CONTROLLED POLYPLEX ASSEMBLY INTEZYNE TECHNOLOGIES, INCORPORATED (US) 2011-10-20 WO disclosed
US-20100172967-A1 COMPOUND MODIFIED WITH GLYCEROL DERIVATIVE KYOWA HAKKO KIRIN CO., LTD. (JP) 2010-07-08 US disclosed
US-7696359-B2 Compound modified with glycerol derivative KYOWA HAKKO KIRIN CO., LTD. (JP) 2010-04-13 US disclosed
US-20100047814-A1 PROTEIN INTERACTION REPORTER AGENTS AND METHODS FOR USING SAME WASHINGTON STATE UNIVERSITY (US) 2010-02-25 US disclosed
EP-1938795-A2 Hair treatment composition, hair treatment agent and method for treating hair by using the same Sunbio, Inc. (KR) 2008-07-02 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20260002946-A1 SURFACE-FUNCTIONALIZED OPTICAL ELEMENT ATR, ATRIP, IGF1R TSHR 65/4885PSMB8 567/4885PSMB5 1829/4885
US-20100172967-A1 COMPOUND MODIFIED WITH GLYCEROL DERIVATIVE NPC1L1, SGMS1, SCARB1 TSHR 2351/4885PSMB8 4796/4885PSMB5 3657/4885
US-20160120994-A1 BLOOD COAGULATION PROTEIN CONJUGATES F13B, F12, F2 TSHR 3460/4885PSMB8 1070/4885PSMB5 795/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.