SCHEMBL12285484

SCHEMBL12285484

CCc1cc(Cc2cc(CC)c(NC(=O)Cc3ccccc3)c(CC)c2)cc(CC)c1NC(=O)Cc1ccccc1

nearest known ligand 0.53

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
EPHX2 P34913 1/20 0.53
HPGD P15428 3/20 0.50
GLS O94925 1/20 0.49
ALDH1A1 P00352 2/20 0.49
L3MBTL1 Q9Y468 1/20 0.49
RAB9A P51151 5/20 0.48
SMN1; SMN2 Q16637 3/20 0.48
GALR3 O60755 1/20 0.48
HTT P42858 1/20 0.48
CCNE1 P24864 1/20 0.48
CDK2 P24941 1/20 0.48
CDK5 Q00535 1/20 0.48
NPC1 O15118 3/20 0.48
GAA P10253 1/20 0.48
KMT2A Q03164 3/20 0.47
MEN1 O00255 2/20 0.47
HDAC8 Q9BY41 1/20 0.47
HDAC6 Q9UBN7 1/20 0.47
USP2 O75604 1/20 0.47
MAPT P10636 1/20 0.47

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL21388008 0.91 HPGD (0.52) EPHX2HPGDGLSALDH1A1L3MBTL1
SCHEMBL12284575 0.89 LMNA (0.50) ALDH1A1L3MBTL1SMN1; SMN2HTTGAA
SCHEMBL12284877 0.86 NLRP3 (0.54) EPHX2HPGDL3MBTL1RAB9ASMN1; SMN2
SCHEMBL16772782 0.85 L3MBTL1 (0.52) HPGDGLSALDH1A1L3MBTL1NPC1
SCHEMBL12284884 0.85 NLRP3 (0.52) HPGDALDH1A1L3MBTL1RAB9ASMN1; SMN2
SCHEMBL12284577 0.84 MEN1 (0.54) EPHX2HPGDALDH1A1SMN1; SMN2KMT2A
SCHEMBL12285451 0.84 NPC1 (0.52) HPGDALDH1A1L3MBTL1SMN1; SMN2HTT
SCHEMBL12674070 0.84 NLRP3 (0.51) EPHX2HPGDL3MBTL1RAB9ASMN1; SMN2
SCHEMBL12284882 0.82 KCNJ5 (0.53) GLSALDH1A1RAB9AHTTNPC1
SCHEMBL12284572 0.82 L3MBTL1 (0.49) HPGDGLSALDH1A1L3MBTL1HTT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8288462-B2 Polyolefin resin composition ADEKA CORPORATION (JP) 2012-10-16 US disclosed
US-20110218279-A1 POLYOLEFIN RESIN COMPOSITION ADEKA CORPORATION (JP) 2011-09-08 US disclosed
EP-2319882-A1 POLYOLEFIN RESIN COMPOSITION Adeka Corporation (JP) 2011-05-11 EP disclosed