Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.75 |
| ▸ | HTT | P42858 | 1/20 | 0.75 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.73 |
| ▸ | MEN1 | O00255 | 5/20 | 0.73 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.70 |
| ▸ | LMNA | P02545 | 3/20 | 0.68 |
| ▸ | NPY1R | P25929 | 1/20 | 0.66 |
| ▸ | NPY2R | P49146 | 1/20 | 0.66 |
| ▸ | TP53 | P04637 | 1/20 | 0.65 |
| ▸ | THRB | P10828 | 1/20 | 0.65 |
| ▸ | RAB9A | P51151 | 1/20 | 0.65 |
| ▸ | USP2 | O75604 | 2/20 | 0.64 |
| ▸ | TSHR | P16473 | 2/20 | 0.64 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.64 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.64 |
| ▸ | POLB | P06746 | 1/20 | 0.64 |
| ▸ | PKM | P14618 | 1/20 | 0.64 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.63 |
| ▸ | HPGD | P15428 | 2/20 | 0.63 |
| ▸ | ESR1 | P03372 | 1/20 | 0.63 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30774061 | 1.00 | L3MBTL1 (0.75) | L3MBTL1HTTKMT2AMEN1ALDH1A1 | |
| SCHEMBL12668678 | 0.85 | MAPT (0.57) | L3MBTL1HTTKMT2AMEN1ALDH1A1 | |
| SCHEMBL25482016 | 0.80 | LMNA (0.82) | L3MBTL1HTTKMT2AMEN1ALDH1A1 | |
| SCHEMBL12285666 | 0.78 | RXFP1 (0.73) | KMT2AMEN1ALDH1A1LMNATP53 | |
| SCHEMBL25481992 | 0.76 | SMN1; SMN2 (0.77) | L3MBTL1KMT2AMEN1ALDH1A1LMNA | |
| SCHEMBL18559224 | 0.76 | USP2 (1.00) | L3MBTL1KMT2AMEN1ALDH1A1LMNA | |
| SCHEMBL12288669 | 0.75 | KMT2A (0.57) | HTTKMT2AMEN1ALDH1A1LMNA | |
| SCHEMBL470775 | 0.74 | MAPT (0.85) | KMT2AMEN1ALDH1A1TP53THRB | |
| SCHEMBL25481977 | 0.73 | SMN1; SMN2 (0.67) | L3MBTL1KMT2AMEN1ALDH1A1LMNA | |
| SCHEMBL12285491 | 0.72 | RXFP1 (1.00) | TP53THRBTDP1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9504676-B2 | Molecules inhibiting a metabolic pathway involving the Syk protein tyrosine kinase and method for identifying said molecules | CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (FR) | 2016-11-29 | — | — | US | disclosed |
| US-9504676-B2 | Molecules inhibiting a metabolic pathway involving the Syk protein tyrosine kinase and method for identifying said molecules | CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (FR) | 2016-11-29 | — | — | US | disclosed |
| US-20140179679-A1 | MOLECULES INHIBITING A METABOLIC PATHWAY INVOLVING THE SYK PROTEIN TYROSINE KINASE AND METHOD FOR IDENTIFYING SAID MOLECULES | CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (FR) | 2014-06-26 | — | — | US | disclosed |
| US-20140179679-A1 | MOLECULES INHIBITING A METABOLIC PATHWAY INVOLVING THE SYK PROTEIN TYROSINE KINASE AND METHOD FOR IDENTIFYING SAID MOLECULES | CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (FR) | 2014-06-26 | — | — | US | disclosed |
| US-20110112098-A1 | MOLECULES INHIBITING A METABOLIC PATHWAY INVOLVING THE SYK PROTEIN TYROSINE KINASE AND METHOD FOR IDENTIFYING SAID MOLECULES | CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (FR) | 2011-05-12 | — | — | US | disclosed |
| US-20110112098-A1 | MOLECULES INHIBITING A METABOLIC PATHWAY INVOLVING THE SYK PROTEIN TYROSINE KINASE AND METHOD FOR IDENTIFYING SAID MOLECULES | CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (FR) | 2011-05-12 | — | — | US | disclosed |
| US-20110112098-A1 | MOLECULES INHIBITING A METABOLIC PATHWAY INVOLVING THE SYK PROTEIN TYROSINE KINASE AND METHOD FOR IDENTIFYING SAID MOLECULES | CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (FR) | 2011-05-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140179679-A1 | MOLECULES INHIBITING A METABOLIC PATHWAY INVOLVING THE SYK PROTEIN TYROSINE KINASE AND METHOD FOR IDENTIFYING SAID MOLECULES | SYK, BTK, TYRO3 | L3MBTL1 2505/4885HTT 4431/4885KMT2A 1901/4885 |
| US-20110112098-A1 | MOLECULES INHIBITING A METABOLIC PATHWAY INVOLVING THE SYK PROTEIN TYROSINE KINASE AND METHOD FOR IDENTIFYING SAID MOLECULES | SYK, BTK, TYRO3 | L3MBTL1 2505/4885HTT 4431/4885KMT2A 1901/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.